Receptor Binding of 6α-Methylprogesterone in Mouse Kidney

Abstract

6α-Methylprogesterone (6MP) is an androgenic progestin that binds to the androgen receptor. However, results from an in vivo study suggested that 6MP was also bound by a second receptor. In the present study, we found that 6MP was bound in kidney cytosol from adrenalectomized/ovariectomized female mice as well as Tfm/Y mice, which lack androgen receptors. 6MP was bound with high affinity (K_d = 1.2 × 10^-8M)by a binder that was present in 7-8 times greater concentration than the androgen receptor and had the specificity of a glucocorticoid receptor. 6MP was bound with similar specificity in liver cytosol. These data indicate that, despite its androgenic effects, 6MP binds primarily to a glucocorticoid receptor in mouse kidney.

"Acetato de medroxiprogesterona administrado em período pré-natal induz hipospádia em machos e virilização em fêmeas de camundongos"

“…Houben e Bullock (1985), descreveram a ação de outro progestágeno, a 6-alfa-metil-progesterona através dos receptores de glicocorticóide, apesar de sua ação androgênica.…”