2011
DOI: 10.1530/eje-10-0904
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Receptor for advanced glycation end-products expression in subcutaneous adipose tissue is related to coronary artery disease

Abstract: Objective: Obesity, a risk factor for coronary artery disease (CAD), is associated with inflammation and reactive oxygen species (ROS) production, while advanced glycation end-products, through their receptor (AGER or RAGE), play an important role on these processes. The aim of this study was to analyze the expression levels of RAGE, NADPH oxidase subunits, and catalase in adipose tissue in relation with CAD. Design and methods: Patients undergoing heart surgery were included in two groups: with and without CA… Show more

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Cited by 26 publications
(18 citation statements)
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“…RAGE is known to be implicated in obesity, diabetes and their complications [50]. This implication is mostly related to its capacity to interact with advanced glycation end products (AGE) [51].…”
Section: Discussionmentioning
confidence: 99%
“…RAGE is known to be implicated in obesity, diabetes and their complications [50]. This implication is mostly related to its capacity to interact with advanced glycation end products (AGE) [51].…”
Section: Discussionmentioning
confidence: 99%
“…Rodino-Janeiro and colleagues examined expression of RAGE and oxidative stress markers in human adipose tissue and the relationship to coronary artery disease [61]. They examined human subjects undergoing heart surgery and divided them into two groups, those with and without coronary artery disease.…”
Section: Age-rage and Oxidative Stress: Evidence From Human Subjectsmentioning
confidence: 99%
“…Recent study in humans shows RAGE mRNA expression in subcutaneous adipose tissues 88 . Although this study does not delineate which cells in adipose tissue express RAGE, our current animal study shows RAGE expression in adipocyte as wells as endothelial cells in adipose tissues 16 .…”
Section: A Rage Adiposity and Atherosclerosis In Mouse Modelmentioning
confidence: 99%