Receptor Interactions in Antidepressant Neurochemical Mechanisms: Modulation by Membrane Components

Brunello, Nicoletta; Cicerano, U.; Rovescalli, A; Riva, Marco; Galimberti, R.; Franzetti, C.; Racagni, Giorgio

doi:10.1007/978-1-4684-5415-4_32

Receptor-Receptor Interactions 1987

DOI: 10.1007/978-1-4684-5415-4_32

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Receptor Interactions in Antidepressant Neurochemical Mechanisms: Modulation by Membrane Components

Nicoletta Brunello¹,

U. Cicerano²,

A Rovescalli³

et al.

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1991

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Cited by 2 publications

References 12 publications

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Effect of Imipramine on the Membrane Anisotropy and on the Phospholipid Methylation in the Central Nervous System of the Rat

Melzacka

Nocon

1991

Journal of Pharmacy and Pharmacology

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An ex-vivo and in-vitro study of the effects of imipramine on the membrane anisotropy and phospholipid methylation in the rat cortical membranes was carried out. A comparative study of the membrane fluidity in various brain regions indicated different basal anisotropy of the areas and different reaction of these membranes to imipramine. It was found that imipramine when given to rats chronically (14 x 10 mg kg-1, i.p.) or added externally to the cortical membranes of naive rats or rats treated with a single dose of imipramine (10 mg kg-1, i.p.) decreased the anisotropy of cortical membranes. Chronic imipramine produced some changes of the membrane architecture in the cortex, whereas imipramine in different concentrations did not fluidize these membranes in-vitro. Imipramine in concentrations corresponding to its mean concentration in the rat brain after administration at a dose of 10 mg kg-1 i.p., potentiated phospholipid methylation in the cortical membranes of naive rats and rats receiving imipramine in a single dose of 10 mg kg-1 i.p. in an in-vitro study, whereas the prolonged administration of imipramine decreased the sensitivity of phospholipid methyltransferases to the stimulating effect of the drug in-vitro.

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Effect of Imipramine on the Membrane Anisotropy and on the Phospholipid Methylation in the Central Nervous System of the Rat

Melzacka

Nocon

1991

Journal of Pharmacy and Pharmacology

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Effect of Some Cationic Amphiphilic Drugs on Phospholipid Methylation in the Central Nervous System of Rats

Nocon

Melzacka

1991

Journal of Pharmacy and Pharmacology

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Imipramine, desipramine, citalopram and chlorpromazine in concentrations which corresponded with their concentration in the central nervous system of rats after pharmacological doses, potentiated phospholipid methylation in the synaptic cortical membranes of naive rats in-vitro. Chronic administration of imipramine, desipramine or citalopram induced changes in the activity of phospholipid methyltransferases since none of these drugs stimulated phospholipid methylation in the synaptic cortical membranes of rats treated with these antidepressants for two weeks. In contrast, chronic treatment with chlorpromazine did not change the sensitivity of phospholipid methyltransferases to the stimulating effect of chlorpromazine, whereas addition of haloperidol to the synaptic cortical membranes of rats treated chronically with haloperidol led to a decrease of phospholipid methylation.

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Receptor Interactions in Antidepressant Neurochemical Mechanisms: Modulation by Membrane Components

Cited by 2 publications

References 12 publications

Effect of Imipramine on the Membrane Anisotropy and on the Phospholipid Methylation in the Central Nervous System of the Rat

Effect of Imipramine on the Membrane Anisotropy and on the Phospholipid Methylation in the Central Nervous System of the Rat

Effect of Some Cationic Amphiphilic Drugs on Phospholipid Methylation in the Central Nervous System of Rats

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