Receptor ontogeny and hormonal imprinting

Csaba, G

doi:10.1007/978-3-0348-9291-9_6

Cited by 26 publications

(29 citation statements)

References 37 publications

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“…Perinatal manipulations of the levels of oxytocin and vasopressin or steroid hormones can alter the long-term programming of oxytocin and vasopressin systems and impact other neurotransmitter systems. This programming phenomenon was first described in rats (Swaab and Boer, 1983;Boer, 1993;Boer et al, 1994) and named 'hormonal imprinting' by Csaba (1986). Reviewed in Bales and Perkeybile (2012), single doses of oxytocin given to newborn prairie vole pups have long-term sex-specific consequences on PVN oxytocin and on other systems such as V1aR and estrogen receptor alpha (Yamamoto et al, 2004(Yamamoto et al, , 2006Kramer et al, 2006;Bales et al, 2007a;Pournajafi-Nazarloo et al, 2007).…”

Section: Oxytocin and Vasopressin Impact Brain Developmentmentioning

confidence: 99%

Developmental Perspectives on Oxytocin and Vasopressin

Hammock

2014

Neuropsychopharmacol

167

146

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The related neuropeptides oxytocin and vasopressin are involved in species-typical behavior, including social recognition behavior, maternal behavior, social bonding, communication, and aggression. A wealth of evidence from animal models demonstrates significant modulation of adult social behavior by both of these neuropeptides and their receptors. Over the last decade, there has been a flood of studies in humans also implicating a role for these neuropeptides in human social behavior. Despite popular assumptions that oxytocin is a molecule of social bonding in the infant brain, less mechanistic research emphasis has been placed on the potential role of these neuropeptides in the developmental emergence of the neural substrates of behavior. This review summarizes what is known and assumed about the developmental influence of these neuropeptides and outlines the important unanswered questions and testable hypotheses. There is tremendous translational need to understand the functions of these neuropeptides in mammalian experience-dependent development of the social brain. The activity of oxytocin and vasopressin during development should inform our understanding of individual, sex, and species differences in social behavior later in life.

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Section: Oxytocin and Vasopressin Impact Brain Developmentmentioning

confidence: 99%

Developmental Perspectives on Oxytocin and Vasopressin

Hammock

2014

Neuropsychopharmacol

167

146

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“…This increase is connected with a rise in Na+/K+-ATPase activity [6] and is partly mediated by growth factors [7], As mentioned in the introduction, several reasons for the more distinct effectiveness of T3 and dexamethasone in young rats with immature kidney function should be consid ered. The main reason could be the undevel oped hormonal regulation of protein synthe sis at the cellular level; there is a postnatal imprinting by various hormones [10,19,20], confirming the existence of a multihormonal sensitive receptor superfamily involved in the growth and differentiation of cells [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…Experiments were performed in rats of various age groups for the following reasons: the extent of PAH transport and its inducibility are dependent on age [1]; there are agedependent differences in the hormonal regu lation of kidney function [9,10], and the mitochondrial activity of rat kidney is low during ontogeny [11].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Triiodothyronine and Dexamethasone on Renal Tubular Transport of p-Aminohippurate in Rats of Different Ages

Bräunlich¹,

Pils²

1992

Dev Pharmacol Ther

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Postnatal maturation of the renal tubular transport of p-aminohippurate (PAH) was verified in rats both in diuresis experiand on renal cortical slices in vitro. Following treatment with various doses of triiodothyronine (T(3)) or dexamethasone (3 days, once a day), the increase in renal tubular transport of PAH was more distinct in young rats with immature kidney function. The synergistic effects of simultaneous treatment with both hormones indicate differences between T(3) and dexamethasone in the modulation of cellular function.

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“…[7][8][9] When a hormone meets its developing target receptor perinatally, hormonal imprinting results, which deeply influences the receptor-hormonesignal transduction complex for life. [10][11][12] However, in this critical period the presence of an excess of the target hormone or hormone analogues (e.g. members of the same hormone family, synthetic hormones, drugs, and environmental pollutants) can cause faulty imprinting with life-long morphological, biochemical, receptorial, behavioural and even genetic consequences.…”

Section: Introductionmentioning

confidence: 99%

Acute and delayed effect of (−) deprenyl and (−) 1-phenyl-2-propylaminopentane (PPAP) on the serotonin content of peritoneal cells (white blood cells and mast cells)

Csaba¹,

Kovács²,

Pállinger³

2005

Cell Biochem. Funct.

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Acute and delayed (hormonal imprinting) effect of (-) deprenyl and its derivative without MAO-B inhibitory activity (-) PPAP, were studied on cells of the peritoneal fluid (lymphocytes, monocytes, granulocytes and mast cells) by flow cytometric and confocal microscopic analysis. Thirty minutes after treatment of 6-week-old female animals, deprenyl was ineffective while PPAP significantly increased the serotonin level of these cells. Three weeks after treatment at weaning, deprenyl drastically decreased the serotonin level of each cell type, while PPAP moderately but significantly increased the serotonin level of monocytes, granulocytes and mast cells. This means that the two related molecules have different effects on the immune cells, which seem to be independent of MAO-B inhibition. The experiments emphasize the necessity of studying the prolonged effects of biologically active molecules, even if they are without acute effects. As serotonin is a modulator of the immune system, the influence on immune cells of the molecules studied can contribute to their enhancing effect.

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Receptor ontogeny and hormonal imprinting

Cited by 26 publications

References 37 publications

Developmental Perspectives on Oxytocin and Vasopressin

Developmental Perspectives on Oxytocin and Vasopressin

Synergistic Effect of Triiodothyronine and Dexamethasone on Renal Tubular Transport of p-Aminohippurate in Rats of Different Ages

Acute and delayed effect of (−) deprenyl and (−) 1-phenyl-2-propylaminopentane (PPAP) on the serotonin content of peritoneal cells (white blood cells and mast cells)

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