Receptor Signaling Pathways in Heart Failure: Transgenic Mouse Models

Chen, Juhsien; Rockman, Howard A.

doi:10.1007/978-1-84628-782-4_10

Cited by 1 publication

(1 citation statement)

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“…Though many of the current murine studies describe the age of the mice as a major factor and most rely on “adult” mice, they do not typically consider gender (for a review, Chen and Rockamn 2008). We propose that because age and gender are important factors in human cardiovascular disease, they should be considered in murine studies.…”

Section: Introductionmentioning

confidence: 99%

Age- and Gender-Related Changes in Ventricular Performance in Wild-Type FVB/N Mice as Evaluated by Conventional and Vector Velocity Echocardiography Imaging: A Retrospective Study

Koch¹,

Haworth²,

Robbins³

et al. 2013

Ultrasound in Medicine & Biology

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Detailed studies in animal models to assess the importance of aging animals in cardiovascular research are rather scarce. The increase in mouse models used to study cardiovascular disease makes the establishment of physiologic aging parameters in myocardial function in both male and female mice critical. Forty-four FVB/N mice were studied at multiple time points between the ages of 3 and 16 mo using high-frequency echocardiography. Our study found that there is an age-dependent decrease in several systolic and diastolic function parameters in male mice, but not in female mice. This study establishes the physiologic age- and gender-related changes in myocardial function that occur in mice and can be measured with echocardiography. We report baseline values for traditional echocardiography and advanced echocardiographic techniques to measure discrete changes in cardiac function in the commonly employed FVB/N strain.

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Section: Introductionmentioning

confidence: 99%