Receptor tyrosine kinases in sinonasal undifferentiated carcinomas—Evaluation for EGFR, c‐KIT, and HER2/neu expression

Chernock, Rebecca D.; Perry, Arie; Pfeifer, John D.; Holden, Joseph A.; Lewis, James S.

doi:10.1002/hed.21061

Cited by 30 publications

(23 citation statements)

References 45 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Novel therapies that have been attempted include boron neutron capture therapy [21], autologous bone marrow transplant [22], and neoadjuvant selective intra-arterial cisplatin with concurrent radiation therapy [23], both of which showed limited success. A recent histo-biochemical study of a small series of SNUC patients showed that these tumours have a strong expression c-KIT, which is a tyrosine kinase receptor typically expressed in gastrointestinal stromal tumours [24]. However, over-expression was not due to an activating mutation in the c-kit gene, and thus, the authors argued that use of TK-inhibitors targeting c-KIT (e.g.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal Undifferentiated Carcinoma (SNUC): The Alberta experience and literature review

Dziegielewski

McGaw

et al. 2013

Journal of Otolaryngology - Head & Neck Surgery

View full text Add to dashboard Cite

BackgroundSinonasal undifferentiated carcinoma (SNUC) is a rare malignancy with often dismal outcomes. This study set to determine provincial and literature-wide survival outcomes based on treatment modality.MethodsRetrospective chart review of all SNUC patients in the province of Alberta from 1986–2010 was conducted. A review of the literature of SNUC patients was also performed. Patient/tumor characteristics, treatment, and follow-up/survival data were collected. Kaplan-Meier and Cox regression survival analyses were performed.Results20 patients were treated for SNUC in Alberta and 140 patients were identified in the literature. Pooled median disease-free survival was 12. 7 months and 5-year survival estimate was 6.25%. Cox-Regression analysis demonstrated an overall survival advantage with multimodality treatments (Log-Rank test: p = 0.015). However, no statistically significant differences in disease-free and overall survival were identified between patients treated with chemoradiation or surgery followed by adjuvant therapy.ConclusionsTreatment of SNUC remains challenging with poor survival outcomes. There appears to be no statistically significant difference in overall, or disease-free survival between treatment modalities.

show abstract

Section: Discussionmentioning

confidence: 99%

Sinonasal Undifferentiated Carcinoma (SNUC): The Alberta experience and literature review

Dziegielewski

McGaw

et al. 2013

Journal of Otolaryngology - Head & Neck Surgery

View full text Add to dashboard Cite

show abstract

“…A nomogram to aid the decision process for or against adjuvant chemoradiation in oral squamous cell includes age, sex, surgical margin status, and tobacco use . Beyond these factors, biological features that reflect the aggressiveness of the disease have proven to be relevant . Exploring the function of different biomarkers offers the opportunity to move from a tumor model of temporal determinism to one of biological determinism, as carcinogenesis is not defined by what stage the patient is in at detection but rather by molecular characteristics of the tumor and the host.…”

Section: Discussionmentioning

confidence: 99%

Prognostic quality of the Union Internationale Contre le Cancer/American Joint Committee on Cancer TNM classification, 7th edition, for cancer of the maxillary sinus

et al. 2014

View full text Add to dashboard Cite

show abstract

“…There is a strong and diffuse expression of epithelial markers (AE1/AE3, CK7, OSCAR, CAM5.2, EMA; Figure 6), consistent p16 and CD117 reactions, and only focal, patchy nuclear reaction with p63, whereas CK5/6, p40, CEA, EBER, CD34, desmin, S100 protein, and calretinin are consistently negative. 53,[56][57][58][59][60][61] Focal, patchy, and/or weak reactions with neuroendocrine markers (NSE, synaptophysin, chromogranin, CD56) may be present, but there is no corresponding neuroendocrine morphology.…”

Section: Mesenchymal Chondrosarcomamentioning

confidence: 99%

Small round blue cell tumors of the sinonasal tract: a differential diagnosis approach

Thompson

2017

Modern Pathology

View full text Add to dashboard Cite

One of the most challenging diagnostic categories within tumors of the sinonasal tract is the small round blue cell tumors. Biopsies are usually small and limited, resulting in considerable diagnostic difficulty for practicing surgical pathologists. These tumors share several overlapping histologic and immunophenotypic findings while also showing considerable variation within and between cases. Specific tumor site of origin, imaging findings, and clinical findings must be combined with the histology and pertinent ancillary studies if the correct diagnosis is to be reached. Discrimination between neoplasms is critical as there are significant differences in therapy and overall outcome. It is important to have a well developed differential diagnosis for this category of tumors, where each of the diagnoses is considered, evaluated, and either confirmed or excluded from further consideration. In an undifferentiated tumor, showing a small round blue cell morphology, using the mnemonic 'MR SLEEP' helps to highlight tumors to consider: melanoma, mesenchymal chondrosarcoma, rhabdomyosarcoma, sinonasal undifferentiated carcinoma, squamous cell carcinoma (including NUT carcinoma), small cell osteosarcoma, lymphoma, esthesioneuroblastoma (olfactory neuroblastoma), Ewing sarcoma/primitive neuroectodermal tumor, pituitary adenoma, and plasmacytoma. A panel of pertinent immunohistochemistry studies, histochemistries and/or molecular tests should aid in reaching a diagnosis, especially when taking the pattern and intensity of reactions into consideration.

show abstract

Receptor tyrosine kinases in sinonasal undifferentiated carcinomas—Evaluation for EGFR, c‐KIT, and HER2/neu expression

Abstract: c-KIT is frequently expressed in SNUC. However, the overexpression is not due to activating mutations or gene amplification.

Cited by 30 publications

References 45 publications

Sinonasal Undifferentiated Carcinoma (SNUC): The Alberta experience and literature review

Sinonasal Undifferentiated Carcinoma (SNUC): The Alberta experience and literature review

Prognostic quality of the Union Internationale Contre le Cancer/American Joint Committee on Cancer TNM classification, 7th edition, for cancer of the maxillary sinus

Small round blue cell tumors of the sinonasal tract: a differential diagnosis approach

Contact Info

Product

Resources

About