Receptors and Aging

In our previous report which indicated volatile anesthetics-induced opisthotonus in mice, we hypothesized that opisthotonus might relate with the rapidity of anesthetic induction, i.e., the blood/gas partition coefficient of the agent. To confirm this, we determined the incidence of opisthotonus induced by four different halogenated ethers (2.0% sevoflurane, 1.3% isoflurane, 2.0% enflurane, and 0.5% methoxyflurane) and 1.0% halothane, a haloalkane, in male ddN mice. The effect of age on opisthotonus was also evaluated by using young (10 +/- 2 weeks), middle-aged (6 +/- 1 mouths), and elderly (12 +/- 1 months) groups of male ddN mice. In each age group, the incidence of opisthotonus occurred in the following order: sevoflurane > isoflurane > enflurane > methoxyflurane > halothane. This partly supports our hypothesis as far as halogenated ethers are concerned. Halothane rarely produced opisthotonus. In the sevoflurane, isoflurane, and methoxyflurane groups, incidence was lower in middle-aged than in young or elderly mice, while incidence increased with age in the enflurane group.

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Epidermal growth factor stimulated protein kinase shows similar activity in liver of senescent and adult mice

Finocchiaro

Komano

Loeb

1985

FEBS Letters

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It was recently reported [(1983) Nature 306, 617-6201 that tyrosine protein kinase activity associated with EGF receptor was absent from senescent human cultured tibroblasts, which are known to have the same number of receptors as young human cultured fibroblasts. We have measured in both adult and senescent C57 black mice the number of EGF receptors, the activity of their associated tyrosine kinase and the activity of the protein phosphatase which dephosphorylates the EGF receptor. We found our results in both groups of animals to be similar which indicate that the observations made in cultured libroblasts cannot be generalized to all mammalian tissues.

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Receptors and Aging

Cited by 3 publications

References 114 publications

Effects of Aging on the Mechanisms of Estrogen Action in Rat Uterus

Effects of Aging on the Mechanisms of Estrogen Action in Rat Uterus

The effects of age and anesthetic solubility on anesthetic-induced opisthotonus in mice

Epidermal growth factor stimulated protein kinase shows similar activity in liver of senescent and adult mice

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