Receptors for thyrotropin-releasing hormone, thyroid-stimulating hormone, and thyroid hormones in the macaque uterus

Hulchiy, Mariana; Zhang, Hua; Cline, J. Mark; Hirschberg, Angelica Lindén; Sahlin, Lena

doi:10.1097/gme.0b013e318252e450

Cited by 18 publications

(17 citation statements)

References 32 publications

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“…The roles of thyroid hormones in uterine physiology and function have received more attentions since the identification of functional thyroid receptors in uteri [ 5 , 13 , 14 ]. From the results of immunohistochemistry, we confirmed that TRα/β was present and located in different cell types of rat uteri, which suggested that there was an important relationship between thyroid hormones and uterine development.…”

Section: Discussionmentioning

confidence: 99%

“…Results from previous investigations, strongly suggest the existence and expression of these receptors in different tissues [ 12 ]. Moreover, several studies have demonstrated that thyroid hormone receptors are expressed in female reproductive organs, such as the human endometrium [ 5 ], macaque uterus [ 13 ] and rat ovary [ 8 ], uterus and oviduct [ 14 ].…”

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confidence: 99%

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Effects of thyroid hormones on the antioxidative status in the uterus of young adult rats

Kong

Fedail

Wei

et al. 2015

Journal of Reproduction and Development

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Thyroid hormones and oxidative stress play significant roles in the normal functioning of the female reproductive system. Nitric oxide (NO), a free radical synthesized by nitric oxide synthases (NOS), participates in the regulation of thyroid function and is also a good biomarker for assessment of the oxidative stress status. Therefore, the purpose of this study was to investigate effects of thyroid hormones on uterine antioxidative status in young adult rats. Thirty immature female Sprague-Dawley rats were randomly divided into three groups: control, hypothyroid (hypo-T) and hyperthyroid (hyper-T). The results showed the body weights decreased significantly in both the hypo-T and hyper-T groups and that uterine weights were decreased significantly in the hypo-T group. The serum concentrations of total triiodothyronine (T3) and thyroxine (T4), as well as estradiol (E2), were significantly decreased in the hypo-T group, but increased in the hyper-T group. The progesterone (P4) concentrations in the hypo- and hyperthyroid rats markedly decreased. Immunohistochemistry results provided evidence that thyroid hormone nuclear receptor α/β (TRα/β) and three NOS isoforms were located in different cell types of rat uteri. The NO content and total NOS and inducible NOS (iNOS) activities were markedly diminished in the hypo-T group but increased in the hyper-T group. Moreover, the activities of both glutathione peroxidase (GSH-Px) and catalase (CAT) exhibited significant decreases and increases in the hypo-T and hyper-T groups, respectively. The malondialdehyde (MDA) contents in both the hypo-T and hyper-T groups showed a significant increase. Total superoxide dismutase (T-SOD) activity in the hypo- and hyper-T rats markedly decreased. In conclusion, these results indicated that thyroid hormones have an important influence on the modulation of uterine antioxidative status.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Effects of thyroid hormones on the antioxidative status in the uterus of young adult rats

Kong

Fedail

Wei

et al. 2015

Journal of Reproduction and Development

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“…Thyroid hormones can influence reproductive function through their effects on gonadotropin-releasing hormone pulse generation, prolactin release, sex hormone-binding globulin turnover, and by binding to thyroid hormone receptors (THRs) in the reproductive tract. 7 The human ovary 43 and the uterus of cynomolgus macaques 44 express THRs. It is possible that THRs are also present in the macaque ovary and function as they do in humans.…”

Section: Discussionmentioning

confidence: 99%

Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis)

Silverstein

Kaplan

Appt³

et al. 2014

Menopause

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Objectives Soy isoflavones are commonly used to alleviate menopause-related symptoms. Menopausal women are at an increased risk for hypothyroidism and there are concerns that isoflavones may be detrimental to thyroid health. The aim of this study was to examine the effects of soy protein and isoflavones on thyroid function and the relationship between thyroid and ovarian function. Methods Adult female cynomolgus monkeys (Macaca fascicularis) were randomized to consume two diets differing only in protein source: casein-lactalbumin (n = 44) or soy protein with isoflavones (n = 41). After 34 months all animals were ovariectomized via laparotomy. Half of the monkeys from each diet treatment group continued to consume their Pre-Ovariectomy treatment phase diet (either SOY [n = 19] or CL [n = 21]) for an additional 34 months. The remaining animals did not continue their diets, and thus were not considered further. Circulating progesterone, triiodothyronine, thyroxine, and thyroid stimulating hormone were measured at baseline. Thyroid hormones were remeasured during each treatment phase. Results Dietary soy increased triiodothyronine in pre-ovariectomized monkeys and prevented a decline in thyroxine following surgical menopause (both p’s < 0.05). Mean progesterone concentrations were positively correlated with triiodothyronine at baseline in pre-ovariectomized monkeys (p < 0.01). Conclusions Progesterone levels and triiodothyronine are positively correlated in macaques. Dietary soy increases triiodothyronine in pre-ovariectomized monkeys and prevents a decline in thyroxine following surgical menopause. The outcomes observed in this study suggest soy protein and isoflavone consumption does not adversely affect and may even preserve thyroid function in postmenopausal women.

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“…Diseases causing overt hyperthyroidism or hypothyroidism can also induce menstrual disorders and fertility consequences. In animal studies, all receptors in the signaling pathway of thyroid hormone function including thyrotropin-releasing hormone (TRH), thyroid-stimulating hormone (TSH), and thyroid hormones were shown to be present in monkey uterus and influenced by long-term steroid hormone treatment (10).…”

Section: Introductionmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

Gaberšček

Zaletel

Schwetz

et al. 2015

European Journal of Endocrinology

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Thyroid disorders, especially Hashimoto's thyroiditis (HT), and polycystic ovary syndrome (PCOS) are closely associated, based on a number of studies showing a significantly higher prevalence of HT in women with PCOS than in controls. However, the mechanisms of this association are not as clear. Certainly, genetic susceptibility contributes an important part to the development of HT and PCOS. However, a common genetic background has not yet been established. Polymorphisms of the PCOS-related gene for fibrillin 3 (FBN3) could be involved in the pathogenesis of HT and PCOS. Fibrillins influence the activity of transforming growth factor beta (TGFb). Multifunctional TGFb is also a key regulator of immune tolerance by stimulating regulatory T cells (Tregs), which are known to inhibit excessive immune response. With lower TGFb and Treg levels, the autoimmune processes, well known in HT and assumed in PCOS, might develop. In fact, lower levels of TGFb1 were found in HT as well as in PCOS women carrying allele 8 of D19S884 in the FBN3 gene. Additionally, vitamin D deficiency was shown to decrease Tregs. Finally, high estrogen-to-progesterone ratio owing to anovulatory cycles in PCOS women could enhance the immune response. Harmful metabolic and reproductive effects were shown to be more pronounced in women with HT and PCOS when compared with women with HT alone or with controls. In conclusion, HT and PCOS are associated not only with respect to their prevalence, but also with regard to etiology and clinical consequences. However, a possible crosstalk of this association is yet to be elucidated.

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Receptors for thyrotropin-releasing hormone, thyroid-stimulating hormone, and thyroid hormones in the macaque uterus

Cited by 18 publications

References 32 publications

Effects of thyroid hormones on the antioxidative status in the uterus of young adult rats

Effects of thyroid hormones on the antioxidative status in the uterus of young adult rats

Effect of soy isoflavones on thyroid hormones in intact and ovariectomized cynomolgus monkeys (Macaca fascicularis)

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

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