Receptors in interstitial cells of Cajal: Identification and possible physiological roles

Vannucchi, Maria Giuliana

doi:10.1002/(sici)1097-0029(19991201)47:5<325::aid-jemt4>3.0.co;2-c

Cited by 43 publications

(30 citation statements)

References 51 publications

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“…The ICC form a complex cellular network that is positioned between nerve endings and smooth muscle cells in the intestinal wall, and functions as a pacemaker system controlling motility and possibly also neurotransmission (Vannucchi 1999). The tyrosine kinase receptor KIT is of vital importance for normal development of the intestinal pacemaker system (Huizinga et al 1995, Hirota et al 1998.…”

Section: Introductionmentioning

confidence: 93%

Gastrointestinal stromal tumors regularly express synaptic vesicle proteins: evidence of a neuroendocrine phenotype

Bümming¹,

Nilsson²,

Ahlman³

et al. 2007

Endocr Relat Cancer

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Gastrointestinal stromal tumors (GISTs) are thought to originate from the interstitial cells of Cajal, which share many properties with neurons of the gastrointestinal tract. Recently, we demonstrated expression of the hormone ghrelin in GIST. The aim of the present study was therefore to evaluate a possible neuroendocrine phenotype of GIST. Specimens from 41 GISTs were examined for the expression of 12 different synaptic vesicle proteins. Expression of synaptic-like microvesicle proteins, e.g., Synaptic vesicle protein 2 (SV2), synaptobrevin, synapsin 1, and amphiphysin was demonstrated in a majority of GISTs by immunohistochemistry, western blotting, and quantitative reversetranscriptase PCR. One-third of the tumors also expressed the large dense core vesicle protein vesicular monoamine transporter 1. Presence of microvesicles and dense core vesicles in GIST was confirmed by electron microscopy. The expression of synaptic-like microvesicle proteins in GIST was not related to risk profile or to KIT/platelet derived growth factor alpha (PDGFRA) mutational status. Thus, GISTs regularly express a subset of synaptic-like microvesicle proteins necessary for the regulated secretion of neurotransmitters and hormones. Expression of synaptic-like micro-vesicle proteins, ghrelin and peptide hormone receptors in GIST indicate a neuroendocrine phenotype and suggest novel possibilities to treat therapy-resistant GIST.

show abstract

Section: Introductionmentioning

confidence: 93%

Gastrointestinal stromal tumors regularly express synaptic vesicle proteins: evidence of a neuroendocrine phenotype

Bümming¹,

Nilsson²,

Ahlman³

et al. 2007

Endocr Relat Cancer

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show abstract

“…Contemporarily, physiologists were able to attribute to them the role of pacemakers for gut peristalsis, being able to generate slow waves (13,(16)(17)(18). Indeed, a combination of morphological and functional investigations was also able to demonstrate that the ICC play a role of intermediate in neurotransmission (12,(17)(18)(19). Another function attributed to some ICC populations is that of being part of the 'stretch receptor'.…”

Section: Interstitial Cells Of Cajal (Icc)mentioning

confidence: 99%

“…Another function attributed to some ICC populations is that of being part of the 'stretch receptor'. In particular, in the small intestine this role would be played by the ICC-DMP (11,12,20,21), in the stomach, by the ICC-IM (22).…”

Section: Interstitial Cells Of Cajal (Icc)mentioning

confidence: 99%

“…All the ICC populations receive nerve terminals; however, great differences in the number and vicinity of these contacts have been described (11) suggesting that there are ICC such as the ICC-DMP almost exclusively engaged in the neurotransmission (12). Moreover, it has been shown that ICC express molecules indicative of their role either in excitatory (NK1 receptor) (32) or inhibitory (nitric oxide synthase) (12,33,34) neurotransmission.…”

Section: Icc and Nerve Contactsmentioning

confidence: 99%

“…methylene blue or silver impregnation) and were located in the interstitium between nerve endings and smooth muscle cells (SMCs) (8). Subsequent work established their structural and functional characteristics and these cells were finally named interstitial cells of Cajal (ICC) (9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

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Interstitial cells of Cajal and telocytes in the gut: twins, related or simply neighbor cells?

Vannucchi

Traini

2016

Biomolecular Concepts

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Abstract:In the interstitium of the connective tissue several types of cells occur. The fibroblasts, responsible for matrix formation, the mast cells, involved in local response to inflammatory stimuli, resident macrophages, plasma cells, lymphocytes, granulocytes and monocytes, all engaged in immunity responses. Recently, another type of interstitial cell, found in all organs so far examined, has been added to the previous ones, the telocytes (TC). In the gut, in addition to the cells listed above, there are also the interstitial cells of Cajal (ICC), a peculiar type of cell exclusively detected in the alimentary tract with multiple functions including pace-maker activity. The possibility that TC and ICC could correspond to a unique cell type, where the former would represent an ICC variant outside the gut, was initially considered, however, further studies have clearly shown that ICC and TC are two distinct types of cells. In the gut, while the features and the roles of the ICC are established, part of the scientific community is still disputing these 'new' interstitial cells to which several names such as fibroblast-like cells (FLCs), interstitial Cajal-like cells or, most recently, PDGFRα + cells have been attributed. This review will detail the main features and roles of the TC and ICC with the aim to establish their relationships and hopefully define the identity of the TC in the gut.

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Introduction to interstitial cells of Cajal

Hanani

1999

Microsc. Res. Tech.

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Receptors in interstitial cells of Cajal: Identification and possible physiological roles

Cited by 43 publications

References 51 publications

Gastrointestinal stromal tumors regularly express synaptic vesicle proteins: evidence of a neuroendocrine phenotype

Gastrointestinal stromal tumors regularly express synaptic vesicle proteins: evidence of a neuroendocrine phenotype

Interstitial cells of Cajal and telocytes in the gut: twins, related or simply neighbor cells?

Introduction to interstitial cells of Cajal

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