Receptors modulation on the ocular surface: A novel insight into the ocular infection and disease transmission of SARS‐COV‐2

Kaushik, Jaya; Singh, Ankita; Kochhar, Divya; Murari, T; Shetty, Rakesh; Parihar, Jitendra Kumar Singh

doi:10.1002/jmv.26858

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…[ 17 ] Suggest a potential upregulation of the ACE2 and its coworker expression on the corneal endothelial layer cells during the course of the disease due to hyperimmune response and cytokine storm indicated by elevated leukocyte levels and superinfection bacterial infection findings such as high procalcitonin, neutrophilia, C-reactive protein, and lactate dehydrogenase. [ 18 19 20 ] The expression of ACE2 on the conjunctiva was shown mostly in the goblet cells. [ 21 ]…”

Section: Potential Mechanism Of Coronavirus Infection Disease-19 Ante...mentioning

confidence: 99%

Manifestations of coronavirus infection disease-19 in anterior eye segment: An up-to-date review

Marzoog

2024

Oman Journal of Ophthalmology

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Coronavirus infection disease-19 (COVID-19) is a worldwide catastrophic emergency that first appeared in late 2019, in Wuhan, China. COVID-19 is a multitropism disease that first affects lung tissue. However, extrapulmonary manifestations have been suspected from the first COVID-19 cases. The ocular signs and symptoms were from the early changes that occur during the course of the disease. Changes in the anterior eye segment have a relatively higher incidence than the posterior eye segment. Of which, conjunctivitis, COVID-19 pharyngioceratoconjuctivitis, iridocyclitis, corneal punctate epitheliopathy, and pathomorphological changes in the physio-anatomy of the anterior eye segment. The potential pathogenesis includes direct penetration of the virus into the eye (conjunctiva, lumbus, and cornea) or due to a systemic pathway through viremia, as well as due to autoimmune antibodies against the ocular structure (immune privilege). The presence of ocular manifestations of the external anterior fibrous layer suggests a mild course of the disease.

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Section: Potential Mechanism Of Coronavirus Infection Disease-19 Ante...mentioning

confidence: 99%

Manifestations of coronavirus infection disease-19 in anterior eye segment: An up-to-date review

Marzoog

2024

Oman Journal of Ophthalmology

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“…SARS-CoV-2 via its surface spike glycoprotein binds to the Angiotensin-Converting Enzyme 2 (ACE2) receptors. These ACE-2 receptors are found distributed in various human organs, including the surface of the cornea and the conjunctiva and these act as potential entry points [9,10]. Coronavirus was spotted in the conjunctival discharge of COVID-19 positive patients [11].…”

Section: Proximity To the Patients During Examinationmentioning

confidence: 99%

SARS-CoV-2: An Ophthalmological Insight into the Pandemic; Challenges and Management Strategies

Kaushik¹,

Shankar²,

Anargh³

et al. 2021

Ann Ophthalmol Vis Sci

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Objective: To formulate a protocol for safe and effective management of an ophthalmologic practice in a hospital or a clinic during the Covid - 19 pandemic. Methods and analysis: Literature was reviewed regarding Covid-19 pandemic and ophthalmology. The following key words were used. Covid-19, telemedicine, challenges, management strategy. Result: An efficient protocol for ophthalmology practice during the Covid-19 pandemic was established which covered various protective measures that are essential and vital in the Covid-19 pandemic. Conclusion: An evidence-based protocol was formulated which may be modified in future as per the latest developments and trends in the ongoing pandemic.

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A cross-sectional comparative analysis of corneal endothelial parameters by specular microscopy in post covid versus normal population in Western India

Anargh¹,

Kaushik²,

Singh³

et al. 2022

HJO

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Objective: To observe the changes in corneal endothelium post COVID-19 infection in different age groups using specular microscopy and compare it with the normal population in western India during the pandemic. Materials and Method: 129 patients COVID-19 recovered, and 123 age-matched healthy controls were included in this cross sectional, comparative, monocentric study. Corneal endothelial parameters like Cell Density (CD) (cell/mm2), Coefficient of Variation (CV) (polymegathism, %), Cell hexagonality (polymorphism, %), Average cell area (MCA) (μm2/cell), and mean value of Central Corneal Thickness (CCT) (μm) were evaluated with a non-contact specular microscope (TOMEY EM-4000, CBD.TOMEY USA) Results: The mean (SD) time since COVID diagnosis (months) in the study group was 6.67 (1.94). The mean (SD) time since RT-PCR negative (months) in the study group was 6.34 (1.74). The mean (SD) of CV (%) in the study group was (RE) 37.75 (6.03), (LE) 36.25 (4.66) and in control group was (RE) 35.23 (3.75), (LE) 34.77 (3.64). The mean (SD) of hexagonality (%) in the study group was (RE) 47.33 (6.84), 48.45 (7.33) and in control group was (RE):56.73 (4.13), (LE) 56.21 (5.34). Conclusion: The specular microscopic examination on the COVID-19 recovered patients revealed a decrease in the hexagonality of the endothelial cells (pleomorphism) and an increase in the cell size (polymegathism). Specular microscopic examination can be done to assess such earliest changes in corneal endothelium to evaluate the effects of the infection following recovery on ocular tissue to avoid long term sequalae.

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Receptors modulation on the ocular surface: A novel insight into the ocular infection and disease transmission of SARS‐COV‐2

Cited by 3 publications

References 11 publications

Manifestations of coronavirus infection disease-19 in anterior eye segment: An up-to-date review

Manifestations of coronavirus infection disease-19 in anterior eye segment: An up-to-date review

SARS-CoV-2: An Ophthalmological Insight into the Pandemic; Challenges and Management Strategies

A cross-sectional comparative analysis of corneal endothelial parameters by specular microscopy in post covid versus normal population in Western India

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