Receptors of Atrial Natriuretic Factor

Maack, Thomas

doi:10.1146/annurev.ph.54.030192.000303

Cited by 283 publications

(127 citation statements)

References 74 publications

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“…One is the biological receptor coupled with guanylate cyclase (ANPb receptor), which is more abundant in the adrenal zona glomerulosa cells than in renal glomeruli, the other, not coupled with guanylate cyclase, is the clearance receptor (ANPc receptor), which is more abundant in renal glomeruli than in adrenal zona glomerulosa and can remove ANP from the blood circulation (47). Both types of ANP receptors are also present in the kidneys and the adrenal glands of the fetal rat at term, in proportions similar to those observed in the adult rat (13).…”

Section: Or Inmentioning

confidence: 99%

Atrial natriuretic peptide and aldosterone secretions, and atrial natriuretic peptide-binding sites in kidneys and adrenal glands of pregnant and fetal rats in late gestation in response to a high-salt diet

Deloof

Seze

Montel

et al. 2000

European Journal of Endocrinology

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Objective: This study aimed at determining, in the term pregnant rat, whether maternal and fetal plasma atrial natriuretic peptide (ANP) concentrations were modified in response to an oral sodium load, and to investigate whether any changes in plasma concentrations were able to modify the density and affinity of the different ANP-binding site subtypes in maternal and fetal kidneys and adrenal glands. Methods: Pregnant rats kept in metabolic cages were divided into two groups. The normal sodium diet group had free access to rat chow and tap water whereas the high sodium diet group received 1% NaCl as drinking water for 10 consecutive days from day 11 to day 21 of gestation with free access to standard rat chow. Pregnant rats from both groups were killed by decapitation on day 21 of gestation. The plasma ANP and aldosterone concentrations were determined by RIA. The density and affinity of ANP receptors were determined in the maternal and fetal adrenal glands and kidneys. Results: In the pregnant rats on the high-salt diet, the sodium and water intakes, as well as the urine volume and sodium excretion, were significantly higher than in the control group. After 10 days of high-salt intake, water and sodium retentions were not significantly different in the two groups, indicating that the pregnant rats were able to excrete excess salt. The high sodium intake did not change the body weight of the pregnant rats but did increase the body weight of the fetal rats. Maternal and fetal hematocrits remained unchanged in both groups, the high sodium intake did not modify plasma sodium concentration in the maternal rats but increased that of the fetuses, indicating an accumulation of sodium in the fetal rats. The dietary sodium intake did not change the plasma ANP concentrations but significantly decreased the plasma aldosterone concentrations in both the maternal and fetal rats. In response to the high-salt diet, the density and affinity of total ANP, ANPb and ANPc receptors were not altered in the maternal isolated renal glomeruli or the adrenal zona glomerulosa membranes or the fetal adrenal gland and kidney membrane preparations. Conclusion: These results suggest that ANP is not involved in the regulation of water and electrolyte balance in maternal and fetal rats during salt-loaded intake.

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Section: Or Inmentioning

confidence: 99%

Atrial natriuretic peptide and aldosterone secretions, and atrial natriuretic peptide-binding sites in kidneys and adrenal glands of pregnant and fetal rats in late gestation in response to a high-salt diet

Deloof

Seze

Montel

et al. 2000

European Journal of Endocrinology

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“…Any signal transduction system associated with this receptor has yet to be clearly demonstrated. ['23I]-ANP binding to the C-receptor is most potently inhibited by ANP, while BNP and CNP appear to be equipotent (Maack, 1992). In rat brain, mRNA for both guanylyl cyclase receptors has been detected (Tallerico-Melnyk et al, 1992), although there is evidence for binding of natriuretic peptides to sites resembling ANPA and C-receptors, but not ANPB receptors (Brown & Zuo, 1993).…”

Section: Introductionmentioning

confidence: 99%

“…C-type natriuretic peptide (CNP), the last member of the natriuretic peptide family discovered (Sudoh et al, 1990), is found almost exclusively in the brain (Ueda et al, 1991) and CNP mRNA also seems to be restricted to brain (Kojima et al, 1990). Molecular cloning studies have identified three natriuretic peptide receptor subtypes (for reviews see Maack, 1992;Garbers, 1992;Levin, 1993). ANPA (or GC-A) and ANPB (GC-B) are monomeric receptors with constitutive guanylyl cyclase activity.…”

Section: Introductionmentioning

confidence: 99%

Natriuretic peptide‐induced cyclic GMP accumulation in adult guinea‐pig cerebellar slices

Hernández

Alexander

Kendall

1994

British J Pharmacology

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“…All three natriuretic peptides also bind the natriuretic peptide clearance receptor, natriuretic peptide receptor-C (NPR-C), which lacks guanylate cyclase activity primarily acting to control the local concentrations of all three natriuretic peptides through receptor mediated internalization and degradation [5,6].…”

Section: Introductionmentioning

confidence: 99%

Relaxant effect of brain natriuretic peptide in nonsensitized and passively sensitized isolated human bronchi

Matera

Calzetta

Parascandolo

et al. 2009

Pulmonary Pharmacology & Therapeutics

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Receptors of Atrial Natriuretic Factor

Cited by 283 publications

References 74 publications

Atrial natriuretic peptide and aldosterone secretions, and atrial natriuretic peptide-binding sites in kidneys and adrenal glands of pregnant and fetal rats in late gestation in response to a high-salt diet

Atrial natriuretic peptide and aldosterone secretions, and atrial natriuretic peptide-binding sites in kidneys and adrenal glands of pregnant and fetal rats in late gestation in response to a high-salt diet

Natriuretic peptide‐induced cyclic GMP accumulation in adult guinea‐pig cerebellar slices

Relaxant effect of brain natriuretic peptide in nonsensitized and passively sensitized isolated human bronchi

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