Rechter Ventrikel bei arterieller Hypertonie

Abstract

Left ventricular hypertrophy is the best known and most evident cardiac organ manifestation of arterial hypertension. However, only limited findings are available on function and structure of the right ventricle. The published studies show that the right ventricle is also affected in the course of hypertensive heart disease. Particularly hypertrophy of the right ventricular free wall, impaired right ventricular diastolic filling, elevated right ventricular filling pressure as well as impairment of right ventricular ejection fraction in the late phase of arterial hypertension were reported. Possible causes of these structural and functional changes of the right ventricle are (1) translation of the increased left ventricular filling pressure in the pulmonary circulation, (2) interaction of the right and left ventricle, and (3) systemic circulation of cytokines and growth hormones such as angiotensin II, aldosterone, and others.

Metabolic Syndrome Impacts the Right Ventricle: True or False?

“…28 However, our study showed that subjects with MS who were free of arterial hypertension and diabetes also had higher prevalence of LV, RV, and biventricular hypertrophy which confirmed the theory that various humoral factors (circulating cytokines and growth hormones) such as angiotensin II, aldosterone, catecholamines, and insulin on both ventricles. 29 The LV structure has a great, perhaps the most significant influence on the RV structure and function, which was confirmed in our study. The analysis of our results showed that the LVMI and RWT were independently associated with the RV wall hypertrophy, which is consistent with the findings from the literature.…”

Metabolic syndrome and biventricular hypertrophy in essential hypertension

“…Briefly, the following mechanisms can be hypothesized: (1) the increased LV filling pressure is translated to the pulmonary circulation, (2) a mechanical interaction occurs between the RV and LV and (3) both ventricles are exposed to humoral stimuli, namely circulating cytokines and growth hormones, such as angiotensin II, aldosterone, catecholamines and insulin. 28 To this purpose, it should be pointed out that our subjects with and without MS were similar for age, known duration of hypertension, as well as SBP and DBP; this supports the view that the prevalence and degree of biventricular involvement was not related to the differences in pressure load or in demographic and clinical variables known to affect cardiovascular structure, but rather to synergic influence of metabolic abnormalities characterizing MS. The difference in RV involvement described in the present study is smaller than previously reported, probably due to the fact that in previous studies hypertensive and normotensive individuals or subjects with and without LVH were compared.…”

Hypertension; The Ice Berg

“…3 Which leads to left ventricular hypertrophy, [3][4][5] CHF, cardiac arrhythmias, diastolic dysfunction and abnormalities of blood flow due to atherosclerotic coronary artery disease and microvascular disease.…”