Rechtliche Grundlagen für den Umgang mit sicherheitsrelevanten Ereignissen in der Strahlentherapie

Lohr, Frank; Baus, Wolfgang; Vorwerk, Hilke; Schlömp, B; André, Louis; Georg, Dietmar; Hodapp, Norbert; Degro, AG Patientensicherheit der; Dgmp,; Ögro, Vmtro sowie für die; Sasro, Ögmp und; Sgsmp,

doi:10.1007/s00066-012-0119-y

Cited by 4 publications

(2 citation statements)

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“…RT has a long tradition in the treatment of desmoids: In 1928, James Ewing, who was the first to propose RT as a treatment option, described that desmoid lesions respond ‘slowly but satisfactorily' to RT [19]. These observations were confirmed by several studies that demonstrated high local control rates after RT [9,12,16,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43]. …”

Section: Discussionmentioning

confidence: 99%

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Radiotherapy Is Effective for Desmoid Tumors (Aggressive Fibromatosis) - Long-Term Results of a German Multicenter Study

et al. 2014

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Background: Desmoids (aggressive fibromatosis) are defined as benign neoplasms of the connective tissue that arise from the deep muscle fascia, aponeurosis, tendons, and scar tissue. Recurrence rates between 40 and 80% were reported after surgery alone. We addressed the impact of radiation therapy (RT) in the management of aggressive fibromatosis. Patients and Methods: A large literature review was performed, and the data was compared with the results of a multicenter study of the German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD). Results: This analysis included 52 patients treated with RT. 37 patients received postoperative RT (20 patients after R2 resection and 17 patients after R1 resection). 15 patients received RT alone (6 patients with inoperable primary tumor and 9 patients with inoperable recurrent tumor). In the case of postoperative RT, a median dose of 50 Gy (range 50-60 Gy) was used; for definitive RT, a median dose of 55 Gy (range 55-65 Gy) was used. The local control rate was 79% for the whole group. The median follow-up was 44 month (range 8-62 months). Conclusion: Given the large number of patients, these data show that RT is highly effective in the treatment of desmoid tumors. RT is an attractive alternative to mutilating surgery.

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Section: Discussionmentioning

confidence: 99%

“…Most authors reported higher local control rates when > 50 Gy were applied, and the doses ranged between 50 and 60 Gy [2,4,22,25,26,27]. Ballo et al [12] described differences in local control for doses < 50 Gy versus > 50 Gy.…”

Section: Discussionmentioning

confidence: 99%