Recipient interleukin 6 gene polymorphism and expression predict HCV recurrence post liver transplantation

Dawood, Reham M.; Salum, Ghada M.; El-Meguid, Mai Abd; Shemis, Mohamed; Aziz, Ahmed Abd El; Awady, Mostafa K. El

doi:10.1016/j.gene.2020.144887

Cited by 12 publications

(4 citation statements)

References 47 publications

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“…Infection with hepatitis C virus can lead to a systemic increase in the production of a variety of in ammatory cytokines, especially interleukin-6 (IL6) and tumor necrosis factor-a (TNF-α). Tumor necrosis factor is a key member of the tumor necrosis factor receptor superfamily (TNFSF), which is produced by the activation of macrophages caused by tissue damage [47][48].…”

Section: Discussionmentioning

confidence: 99%

Is There a Relationship Between Psoriasis and Hepatitis C?: a Meta-analysis and Bioinformatics Investigation

Liu

Cui

Duan

et al. 2021

Preprint

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Background: The relationship between psoriasis and hepatitis C was previously controversial, so our purpose is to investigate this connection.Methods: We conducted a systematic review of the case-control, cross-sectional and cohort studies examining the association between psoriasis and hepatitis C in PubMed, EMBASE and Cochrane library databases and investigated the overlapping genes between psoriasis targets and hepatitis C targets using bioinformatics analysis. Based on overlapping genes and hub nodes, we also constructed the protein-protein interaction (PPI) network and module respectively, followed by the pathway enrichment analysis. Results: We included 11 publications that reported a total of 11 studies (8 cross-sectional and 3 case-control). The case–control and cross-sectional studies included 25,047 psoriasis patients and 4,091,631 controls in total. Psoriasis was associated with a significant increase of prevalent hepatitis C (OR 1.72; 95% confidence interval [CI] (1.17-2.52)). A total of 389 significant genes were common to both hepatitis C and psoriasis, which mainly involved IL6, TNF, IL10, ALB, STAT3 and CXCL8. The module and pathway enrichment analyses showed that the common genes had the potential to influence varieties of biological pathways, including the inflammatory response, cytokine activity, cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, which play an important role in the pathogenesis of hepatitis C and psoriasis.Conclusion: Patients with psoriasis display increased prevalence of hepatitis C and the basic related mechanisms between hepatitis C and psoriasis had been preliminarily clarified.

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Section: Discussionmentioning

confidence: 99%

Is There a Relationship Between Psoriasis and Hepatitis C?: a Meta-analysis and Bioinformatics Investigation

Liu

Cui

Duan

et al. 2021

Preprint

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“… 40 Hepatic inflammation, including the innate immune cell stimulation and cytokine generation, is a master cause for liver injury. 41 , 42 IL-6 secreted into the liver during the initial stages of inflammation induces an enormous number of proteins, 43 including CRP, fibrinogen, haptoglobin, alpha-antitrypsin and serum amyloid A (SAA). On the contrary, IL-6 was reported to lessen albumin, fibronectin, and transferrin generation.…”

Section: Introductionmentioning

confidence: 99%

The Impact of COVID-19 on Liver Injury

Dawood

Salum

El-Meguid

2022

The American Journal of the Medical Sciences

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“…On other point of view, the recipient genotype is more feasible and obtainable before transplantation earlier than the donor genotype. However, many studies correlated only the recipient genotype (for TLR4, IL6, and IL-28B SNPs) with the HCV recurrence [28,41,45,46], and more attention is needed to identify new predictors.…”

Section: Discussionmentioning

confidence: 99%

“…Theoretically, CRS may be used to stratify patients who are eligible for OLT or not better than a liver biopsy. The latter represents a single time point in the extended natural history of chronic infection, while genetic markers are and “life-long.” Also, we have a growing base of evidence linking a variant in the IL6 rs1800795 G allele with HCV recurrence post-LT [ 28 ]. Moreover, we finished a promising study which validated CRS performance in 240 Egyptian HCV-infected patients with different fibrosis grades [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of seven gene signature for predicting HCV recurrence post-liver transplantation

Salum

El-Meguid

Abelhafez

et al. 2021

Journal of Genetic Engineering and Biotechnology

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Background Orthotropic liver transplantation (OLT) offers a therapeutic choice for hepatocellular carcinoma (HCC) patients. The poor outcome of liver transplantation is HCV recurrence. Several genome-wide associated studies (GWAS) have reported many genetic variants to be associated with HCV recurrence. Seven gene polymorphisms formed a cirrhosis risk score (CRS) signature that could be used to distinguish chronic HCV patients at high risk from those at low risk for cirrhosis in non-transplant patients. This study aims to examine the association of CRS score and other clinical parameters with the probability for HCC emergence and/or the rate of HCV recurrence following liver transplantation. Results Seven gene polymorphisms, forming the CRS, were genotyped by real-time PCR using allelic discrimination protocol in 199 end-stage liver disease patients (79 child A, 43 child B, and 77child C), comprising 106 patients who encountered liver transplantation. Recipient CRS scores were correlated with HCV recurrence (HCV-Rec) at the end of the third year after OLT. Around 81% (39) recipients with low steatosis (LS; < 3.5%) donor percentage revealed no HCV recurrence (non-Rec) (p<0.001). CRS score could distinguish between child A, child B, and child C only at the low-risk group. Among the HCV Rec group 27% (8/30), 40% (12/30), and 33% (10/30) fell into the high, moderate, and low CRS risk groups, respectively. Stepwise logistic regression evinced two features more likely to be seen in HCV-Rec patients: abnormal ALT [OR, 1.1; 95% CI, 1.02–1.2] and donor steatosis >3.5% [OR, 46.07; 95% CI, 1.5–1407.8]. Conclusions Accordingly, the CRS score seems to be less useful to predict HCV recurrence after OLT. ALT and donor steatosis (exceed 3.5%) can significantly promote the HCV recurrence post-OLT. Moreover, the combination of MMF and CNI positively heightens HCV recurrence.

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Recipient interleukin 6 gene polymorphism and expression predict HCV recurrence post liver transplantation

Cited by 12 publications

References 47 publications

Is There a Relationship Between Psoriasis and Hepatitis C?: a Meta-analysis and Bioinformatics Investigation

Is There a Relationship Between Psoriasis and Hepatitis C?: a Meta-analysis and Bioinformatics Investigation

The Impact of COVID-19 on Liver Injury

Evaluation of seven gene signature for predicting HCV recurrence post-liver transplantation

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