Recipient Monitoring

Effect of leukoreduction on inflammation in critically ill dogs receiving red blood cell transfusions: A randomized blinded controlled clinical trial

“…However, we believe our trial best reflects clinical practice where variably aged blood will be available for any given transfusion and therefore would provide the most relevant data regarding the effect of LR on post-transfusion inflammation. The median age of transfused RBC bags in our study was not different between groups, at 21 (14-31) days for LR and 25 (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34) days for NLR. From previous in vitro analyses, we expected accumulation of IL-8 in NLR but not in LR RBC bags over time, with the highest concentration in older NLR bags.…”

“…Monitoring and data collection were performed by clinical staff and final year veterinary students. Any observed signs consistent with a transfusion reaction (including urticaria, facial edema, acute hypotension, pigmenturia, tachypnea, ptyalism, regurgitation, or vomiting) were reviewed by the clinician on duty, who then decided if cessation of transfusion or treatment or both was indicated 25 . All adverse events and interventions were recorded on the patient's case report form.…”

“…Any observed signs consistent with a transfusion reaction (including urticaria, facial edema, acute hypotension, pigmenturia, tachypnea, ptyalism, regurgitation, or vomiting) were reviewed by the clinician on duty, who then decided if cessation of transfusion or treatment or both was indicated. 25 All adverse events and interventions were recorded on the patient's case report form. The ages of the transfused RBC bags in days for each dog were calculated and recorded on a patient demographic spreadsheet after study completion.…”

Prevalence of dog erythrocyte antigen 1 in a population of dogs tested in California

“…Determination of patient blood types is important to help prevent life-threatening acute hemolytic transfusion reactions (AHTRs). 1 Blood groups are defined by species-specific, inherited antigens on the RBC surface.…”

“…© Veterinary Emergency and Critical Care Society 2022. canine blood groups described, but those that are internationally recognized include DEA 1, DEA 3, DEA 4, DEA 5, and DEA 7. 1 Dal, Kai 1, and Kai 2 are more recently discovered antigens that have been shown to be independent from known DEA systems and have not received a DEA designation. 2,3 In dogs, DEA 1 is considered the most immunogenic antigen and therefore the most clinically important.…”