Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression

Chiara, G. Di; Loddo, P.

doi:10.1016/s0006-3223(99)00236-x

Cited by 233 publications

(153 citation statements)

References 43 publications

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“…The current studies demonstrate that HCRT elicits an activation of PFC DA systems comparable to that observed in both aversive and appetitive high-arousal states (Abercrombie et al, 1989;Cenci et al, 1992;Gresch et al, 1994;Di Chiara et al, 1999;Feenstra et al, 2000), and that this involves, at least in part, actions within the VTA. These observations suggest that HCRT contributes to the relatively selective activation of PFC DA projections under appetitive and/or aversive conditions.…”

Section: Hcrt-da Interactions In Aversive and Appetitive Conditionssupporting

confidence: 59%

“…These observations suggest that HCRT contributes to the relatively selective activation of PFC DA projections under appetitive and/or aversive conditions. It should be noted that, often, stress-related increases in PFC DA release are accompanied by smaller, though substantial, increases in Acc DA release (Abercrombie et al, 1989;Cenci et al, 1992;Gresch et al, 1994;Di Chiara et al, 1999;Feenstra et al, 2000). Thus, the effect of HCRT-1 on DA neurotransmission is not entirely similar to that observed in stress.…”

Section: Hcrt-da Interactions In Aversive and Appetitive Conditionsmentioning

confidence: 97%

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Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area

Vittoz

Berridge

2005

Neuropsychopharmacol

171

114

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Hypocretins (HCRTs) modulate a variety of behavioral and physiological processes, in part via interactions with multiple ascending modulatory systems. Further, HCRT efferents from the lateral hypothalamus innervate midbrain dopamine (DA) nuclei, and DA cell bodies express HCRT receptors. Combined, these observations suggest that HCRT may influence behavioral state and/or statedependent processes via modulation of DA neurotransmission. The current studies used in vivo microdialysis in the unanesthetized rat to first characterize the effect of intracerebroventricular infusion of HCRT-1 (0.07, 0.7 nmol) on extracellular levels of DA within the prefrontal cortex (PFC) and nucleus accumbens (Acc). Electroencephalographic/electromyographic measures of sleep-wake state were collected along with select behavioral measures (eg locomotor activity, grooming). HCRT-1 dose-dependently increased PFC dialysate DA levels, and these increases were closely correlated with increases in time spent awake. In contrast, Acc DA levels were unaffected. Additional studies examined whether HCRT-1 acts directly within the ventral tegmental area (VTA) to selectively increase PFC DA efflux and modulate behavioral state. Unilateral infusion of HCRT-1 (0.1, 1.0 nmol) within the VTA increased PFC, but not Acc, DA levels. Importantly, intra-VTA infusion of HCRT-1 increased the time spent awake and grooming. Moreover, HCRT-induced increases in both time spent awake and time spent grooming were significantly correlated with post-infusion PFC DA levels. The current observations predict a prominent modulatory influence of HCRT on PFC-dependent cognitive and affective processes that results, in part, from actions within the VTA. Additionally, these observations suggest that the activation of VTA DA neurons contributes to the behavioral state-modulatory actions of HCRT.

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Section: Hcrt-da Interactions In Aversive and Appetitive Conditionssupporting

confidence: 59%

Section: Hcrt-da Interactions In Aversive and Appetitive Conditionsmentioning

confidence: 97%

Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area

Vittoz

Berridge

2005

Neuropsychopharmacol

171

114

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“…Food and water were available ad libitum except during the food and/or water deprivation periods of the CMS procedures. Rats were exposed to CMS for 19 d from Monday morning, which consisted of the administration of various stressors, as previously described (Moreau et al, 1996;Di Chiara et al, 1999). The stressors included repeated 1 h periods of confinement to a small cage (24 × 10 × 9 cm), one period of continuous overnight illumination, one overnight period of food and water deprivation followed by 2 h of access to restricted food (3 g per cage), one overnight period of water deprivation followed by 1 h exposure to an empty bottle, one overnight period of group housing (6 rats per cage) in a soiled cage (200 ml of water in sawdust bedding).…”

Section: Animals and Chronic Mild Stress Exposurementioning

confidence: 99%

Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus

Lee

Kim²,

Kim³

et al. 2006

Exp Mol Med

112

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New-born cells continue to proliferate and survive to become mature granule cells in adult rat hippocampus. Although this process, known as neurogenesis, is inhibited by acute stress, it is not clear whether chronic stress affects neurogenesis. To determine whether chronic mild stress (CMS) influences neurogenesis in the adult rat hippocampus, male Sprague-Dawley rats were exposed to CMS and administered bromodeoxyuridine (BrdU) before or after CMS to observe the survival/differentiation or proliferation of new-born cells, respectively. In addition, we measured brain-derived neurotrophic factor (BDNF) mRNA in the granule cell layer (GCL) of the hippocampus, because BDNF is known to play an important role in the survival of new-born cells. CMS significantly decreased the survival of newborn cells in the GCL, but did not influence the proliferation or differentiation of new-born cells. CMS did not affect the proliferation and survival of new-born cells in the hilus. In addition, CMS did not change BDNF mRNA levels in the GCL. These results demonstrate that CMS reduces the survival of new-born cells but not of their proliferation, suggesting that repeated mild stress could influence a part of neurogenesis, but not the whole part of neurogenesis. These results raise the possibility that the survival of new-born cells may be suppressed in the presence of normal BDNF mRNA levels in GCL.

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“…The prefrontal cortex (PFCX) is thought to play an important role in the pathogenesis of major psychiatric conditions and in the mechanism of drugs utilized for their treatment (Tanda et al 1994;Drevets et al 1998;Di Chiara et al 1999;Robbins 2000;Weinberger et al 2001). This role might be related to an action on and to an interaction among the three monoaminergic inputs to the PFCX, noradrenergic, serotonergic and dopaminergic (Millan et al 2000b).…”

mentioning

confidence: 99%

Noradrenaline transporter blockers raise extracellular dopamine in medial prefrontal but not parietal and occipital cortex: differences with mianserin and clozapine

Valentini

Frau

Chiara

2004

Journal of Neurochemistry

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This study compared the interaction between noradrenaline (NA) and dopamine (DA) mechanisms in the prefrontal (PFCX) and in the parietal (ParCX) and occipital (OccCX) cortex. The effect of reboxetine and desipramine, two NA transporter blockers, of mianserin, an antagonist of a 2 and 5-HT2 receptors, and of clozapine, an atypical antipsychotic, on dialysate DA in the medial PFCX, ParCX and OccCX was studied. We also assessed the influence of a prior 6-hydroxydopamine (6-OHDA) lesion of the dorsal noradrenergic bundle (DNAB) on the effect of reboxetine and clozapine on dialysate DA in the PFCX and ParCX. Systemic administration of reboxetine and desipramine dose-dependently increased dialysate DA in the PFCX but not in the ParCX and OccCX. In contrast, mianserin and clozapine raised dialysate DA in the ParCX and OccCX to an even larger extent than in the PFCX. 6-OHDA lesions of DNAB abolished the increase of dialysate DA elicited by reboxetine in the PFCX and by clozapine both in the PFCX and in the ParCX. It is concluded that, although PFCX and ParCX/OccCX share the presence of a strong control of DA transmission by NA through a 2 receptors, they differ in the extent to which DA is cleared from the extracellular compartment by uptake through the NA transporter. This process, although extensive in the PFCX, appears insignificant in the ParCX and OccCX, probably as a result of the higher ratio of NA to DA resulting in exclusion of DA from NA transporter.

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Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression

Cited by 233 publications

References 43 publications

Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area

Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area

Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus

Noradrenaline transporter blockers raise extracellular dopamine in medial prefrontal but not parietal and occipital cortex: differences with mianserin and clozapine

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