Reciprocal changes in the firing rate of neostriatal and dorsal raphe neurons following local infusions or systemic injections of D- amphetamine: evidence for neostriatal heterogeneity

Rebec, GV; Curtis, SD

doi:10.1523/jneurosci.03-11-02240.1983

Cited by 31 publications

(13 citation statements)

References 62 publications

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“…1, Table 1), MP (Fig. 2), APO (Table 2), and amfonelic acid (Waldmeier et al 1983) may reflect stimulant-induced increases in the activity of DRN 5HT neurons, Consistent with this interpretation, Gallagher and Aghajanian (1976) reported that 3 mg/kg AMPH increased the firing rate of DRN neurons, and Rebec and Curtis (1983) have shown that moderate doses of AMPH produce a prolonged increase in activity of cells recorded from the DRN. Further, Geyer and his coworkers have noted that stereotypic doses of AMPH and MP (Geyer et al 1975) and doses of APO above 0.1 mg/kg (Lee and Geyer 1982) alter cytofluorometric measures of cellular 5HT in a manner consistent with enhanced 5HT release and utilization in DRN but not in median raphe.…”

Section: Discussionmentioning

confidence: 72%

“…In contrast to these high dose effects of AMPH, electrophysiological (Foote et al 1969;Gallagher and Aghajanian 1976; Baraban et al 1978 ;Rebec and Curtis 1983) and cytofluorometric (Geyer et al 1975) data indicate profound effects on apparent 5HT function at moderate doses of AMPH which enhance locomotor activity or promote focused stereotypies. Further, some evidence suggests a role for 5HT in modulating both AMPH-induced locomotor activity (Neill et al 1972;Mabry andCampbell 1973, Breese et al 1974;Costall and Naylor 1974) and stereotypies (Sega11976; Sloviter et al 1978 b;Lucki and Harvey 1979).…”

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confidence: 96%

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Effects of amphetamine, methylphenidate, and apomorphine on regional brain serotonin and 5-hydroxyindole acetic acid

et al. 1987

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Electrophysiological and cytofluorometric data suggest that doses of amphetamine which enhance locomotor activity and promote focused stereotypies produce pronounced effects on serotonin pathways in the CNS. However, the biochemical evidence regarding changes in serotonergic function produced by moderate doses of this drug is inconsistent. Therefore, the present study was designed to further examine the effects of amphetamine (1-5 mg/kg) on regional brain serotonin and its metabolite and to compare these effects to behaviorally comparable doses of methylphenidate and apomorphine. At doses which produce a multiphasic behavioral response pattern, including a stereotypy phase consisting primarily of repetitive head movements and occasional oral stereotypies, amphetamine (3 mg/kg) and methylphenidate (30 mg/kg) increased levels of 5HIAA in striatum and frontal cortex, two brain regions which receive serotonergic projections from the dorsal raphe nucleus. In contrast, these drugs decreased or had no effect on 5HIAA levels in hippocampus, a brain region which receives its serotonergic innervation from the median raphe nucleus. A moderate dose of apomorphine (0.5 mg/kg) produced a comparable pattern of neurochemical effects. These data are consistent with electrophysiological and cytofluorometric data suggesting enhanced dorsal raphe serotonergic function following amphetamine-like stimulants. Pretreatment of animals with alpha-methyltyrosine at a dose sufficient to prevent the locomotor stimulation and stereotypy promoted by amphetamine, or by haloperidol, failed to prevent the amphetamine-induced increase in 5HIAA, indicating that these serotonergic effects are not secondary to the amphetamine facilitation of dopaminergic transmission.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 72%

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confidence: 96%

Effects of amphetamine, methylphenidate, and apomorphine on regional brain serotonin and 5-hydroxyindole acetic acid

et al. 1987

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“…Serotonergic systems have long been suspected of modulating amphetamineinduced stereotypy (see Segal and Kuczenski 1994) and are known to influence striatal neuronal activity (Rebec and Curtis 1983). Amphetamine-induced interactions between dopamine and serotonin are likely at the neuronal level and should be pursued in future work with behaving animals.…”

Section: Discussionmentioning

confidence: 99%

Responses of neurons in dorsal striatum during amphetamine-induced focused stereotypy

1997

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The phase of highly focused, repetitive behavior (stereotypy) induced by amphetamine in rats emerges after an initial period of locomotor activation. To assess the neuronal correlates of this behavioral transition, single-unit activity was recorded from the dorsal striatum of awake, unrestrained rats. Units were first characterized in terms of their responsiveness to spontaneous movement. Various types of motor-related neurons were identified. Some increased activity above resting baseline during specific movements such as forward locomotion or turning of the head, while others were excited during periods of general behavioral activation. Neurons that showed no consistent change in firing rate during overt movement were classified separately. Administration of 5.0 mg/kg d-amphetamine caused a steady increase in the overall neuronal response through both the locomotor and stereotypy phases. An analysis of specific neuronal types, however, revealed distinct, phase-related shifts in firing rate. Locomotor-related neurons discharged rapidly during the early phase of the amphetamine response and then declined toward baseline as focused stereotypy emerged. Cells found to be excited primarily during head movements showed relatively small changes shortly after drug administration but increased markedly in conjunction with intense head-movement activity associated with focused stereotypy. Other neurons, which increased activity nonselectively to a wide range of movements, showed progressive increases in firing rate during both behavioral phases elicited by the drug. Subsequent administration of 1.0 mg/kg haloperidol typically reversed the neuronal changes and blocked amphetamine-induced focused stereotypy. Nonmotor-related cells responded inconsistently to amphetamine, showing an inhibition, excitation, or no change in rate. Previous assessments of neuron-behavior relationships have shown that changes in motor-related neuronal activity are not secondary to amphetamine-induced behavioral changes, though this finding may not apply in all cases. At doses capable of eliciting focused stereotypy, therefore, amphetamine appears to trigger a complex pattern of striatal activity that governs the behavioral response. This conclusion supports steadily increasing evidence that the role of striatal neurons in amphetamine-induced focused stereotypy is shaped by multiple synaptic mechanisms.

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“…Will et al (1998Will et al ( , 2002 suggested that these results might have been a product of the interaction between the sensitization of DRN neurons selectively produced by IS and dopaminergic (DA) processes in either the nucleus accumbens (NAc) or the medial prefrontal cortex (mPFC). Serotonin in these structures can potentiate DA release (Rasmusson et al, 1994), and it is noteworthy that morphine activates DRN 5-HT neurons (Tao and Auerbach, 1994) but amphetamine does not (Rebec and Curtis, 1983). Given that IS sensitizes DRN 5-HT neurons, morphine might be expected to produce exaggerated extracellular levels of 5-HT in projection regions of the DRN such as the mPFC in subjects that had been previously exposed to IS, thereby potentiating DA levels in them and thus potentiating reward-related processes.…”

Section: Introductionmentioning

confidence: 99%

Stressor Controllability Modulates Stress-Induced Dopamine and Serotonin Efflux and Morphine-Induced Serotonin Efflux in the Medial Prefrontal Cortex

Bland

Hargrave

Pepin

et al. 2003

Neuropsychopharmacol

137

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It has previously been shown that inescapable (IS) but not escapable (ES) stress potentiates the rewarding properties of morphine as measured by conditioned place preference and psychomotor activation, and that this potentiation may be mediated by dorsal raphe nucleus (DRN) serotonin (5-HT) neurons. The medial prefrontal cortex (mPFC) has been implicated in both reward and stress, and is a projection region of the DRN. The mPFC also contains dopaminergic afferents from the ventral tegmental area, which has been the focus of many studies exploring both the rewarding properties of drugs and the aversive properties of stress. The role of the mPFC in stress/ drug reactivity interactions is largely unknown. The present study usedin vivo microdialysis to examine 5-HT and dopamine (DA) efflux in the mPFC of rats during IS, ES or no stress (NS). IS and ES rats received the stressor in yoked pairs. The stressor consisted of tailshocks that could be terminated for both rats by the ES rats. Large increases in 5-HT and DA levels were observed during IS but not ES or NS. DA and 5-HT efflux were also measured 24 h later in the same rats in response to morphine (3 mg/kg) or saline. Sustained increases in 5-HT levels were observed after morphine in rats that had previously received IS but not in rats that had received ES or NS. No changes in DA efflux were observed after morphine. Thus, 5-HT and DA in the mPFC may be involved in stressor controllability effects, and the sensitization of 5-HT neurons by IS extends to the mPFC and to morphine as a challenge.

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Reciprocal changes in the firing rate of neostriatal and dorsal raphe neurons following local infusions or systemic injections of D- amphetamine: evidence for neostriatal heterogeneity

Cited by 31 publications

References 62 publications

Effects of amphetamine, methylphenidate, and apomorphine on regional brain serotonin and 5-hydroxyindole acetic acid

Effects of amphetamine, methylphenidate, and apomorphine on regional brain serotonin and 5-hydroxyindole acetic acid

Responses of neurons in dorsal striatum during amphetamine-induced focused stereotypy

Stressor Controllability Modulates Stress-Induced Dopamine and Serotonin Efflux and Morphine-Induced Serotonin Efflux in the Medial Prefrontal Cortex

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