2009
DOI: 10.2478/v10039-009-0024-5
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Reciprocal chromosome translocations involving short arm of chromosome 9 as a risk factor of unfavorable pregnancy outcomes after meiotic malsegregation 2:2

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Cited by 4 publications
(3 citation statements)
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“…According to some authors, as male carriers of translocations have reduced fertility, chromosomal abnormalities in the female partner are a more common finding in couples with recurrent miscarriages 8 . The significant increase in reciprocal translocation in couples with reproductive failure is an expected finding because the carriers of reciprocal translocation have a significantly increased risk of chromosomal imbalance (partial chromosomal duplication/deficiency) during gametogenesis due to unequal meiotic segregation of the balanced translocation 13,17,18 .…”
Section: Discussionmentioning
confidence: 99%
“…According to some authors, as male carriers of translocations have reduced fertility, chromosomal abnormalities in the female partner are a more common finding in couples with recurrent miscarriages 8 . The significant increase in reciprocal translocation in couples with reproductive failure is an expected finding because the carriers of reciprocal translocation have a significantly increased risk of chromosomal imbalance (partial chromosomal duplication/deficiency) during gametogenesis due to unequal meiotic segregation of the balanced translocation 13,17,18 .…”
Section: Discussionmentioning
confidence: 99%
“…The probability rate for unbalanced progeny with trisomy/monosomy of the 9p11.2 segment after adjacent-1 segregation at birth for paternal carriers was estimated at 11.8%, and the odds of unbalanced progeny at prenatal diagnosis was 57% [49]. The probability of natural conception was very low, but an option for ICSI after testicular biopsy and pre-implantation genetic diagnosis was discussed with the couple because the presence of immature germ cells in the ejaculate could indicate spermatogenic activity in the testes [50].…”
Section: Discussionmentioning
confidence: 99%
“…In general, the results of Panasiuk et al [11] on carriers with a breakpoint position at 9p22, at 9p13 and at 9p11.2 showed that reciprocal chromosome translocations involving the short arm of chromosome 9 as a risk factor of unfavorable pregnancy outcomes. There are other reports that confirm facial malformations in trisomy 9p patients[12–22].…”
Section: Cytogenetic Studymentioning
confidence: 99%