Reciprocal interaction between striatal cholinergic and low‐threshold spiking interneurons — A computational study

Nylén, Johanna; Carannante, Ilaria; Grillner, Sten; Kotaleski, Jeanette Hellgren

doi:10.1111/ejn.14854

Cited by 15 publications

(11 citation statements)

References 72 publications

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“…Consistent with previous studies, we found that optogenetic stimulation of CINs evoke a long pause in the firing activity of LTSIs that is mediated mostly by mAChRs activation and a participation of GABA A receptors certainly via CIN-activation of THINs 5,6,14,53,54 . Here, in addition to confirming these data, we also show the presence of an EPSC/P in most recorded LTSIs that involve both nAChRs and glutamate receptor activation.…”

Section: Discussionsupporting

confidence: 92%

Cholinergic control of striatal GABAergic microcircuits

Kocatürk

Shah

Guven

et al. 2021

Preprint

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Cholinergic interneurons (CINs) are essential elements of striatal circuits and behaviors. While acetylcholine signaling via muscarinic receptors (mAChRs) have been well studied, more recent data indicate that postsynaptic nicotinic receptors (nAChRs) located on GABAergic interneurons (GINs) are equally critical. One demonstration is that CINs stimulation induces large disynaptic inhibition of SPNs mediated by nAChR activation of striatal GINs. While these circuits are ideally positioned to modulate striatal output activity, the neurons involved are not definitively identified due largely to an incomplete mapping of CINs-GINs interconnections. Here, we show that CINs optogenetic activation evokes an intricate dual mechanism involving co-activation of pre- and postsynaptic mAChRs and nAChRs on four GINs populations. Using multi-optogenetics, we demonstrate the participation of tyrosine hydroxylase-expressing GINs in the disynaptic inhibition of SPNs likely via heterotypic electrical coupling with neurogliaform interneurons. Altogether, our results highlight the importance of CINs in regulating GINs microcircuits via complex synaptic/heterosynaptic mechanisms.

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Section: Discussionsupporting

confidence: 92%

Cholinergic control of striatal GABAergic microcircuits

Kocatürk

Shah

Guven

et al. 2021

Preprint

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“…37 By virtue of their unique reward-associated modulation, 2 LTSIs are ideally situated to control the timing and magnitude of dopamine signals during learning. In addition to directly gating striatal dopamine, LTSIs further participate in this local modulatory microenvironment through strong inhibitory control over ChINs, [38][39][40][41] which also directly and strongly regulate striatal dopamine. [8][9][10][11][12] As both LTSIs and ChINs are dynamically modulated by discrete components of reward learning and performance, future work should delineate how these interneurons work in concert to shape dopamine signals during ongoing goal-directed behavior.…”

Section: Reportmentioning

confidence: 99%

Striatal low-threshold spiking interneurons locally gate dopamine

et al. 2021

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Striatal low-threshold spiking interneurons locally gate dopamine Highlights d Striatal low-threshold spiking interneurons (LTSIs) synapse near dopamine terminals d In vitro, LTSIs directly and locally reduce striatal dopamine via GABA B signaling d In vivo, LTSIs strongly modulate striatal dopamine dynamics during operant learning d Local D2 partial agonism suggests that LTSI-dopamine interactions underlie learning

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“…In another study from the same research team, the authors used computational modelling to examine the reciprocal interactions between striatal cholinergic interneurons and low-threshold spiking (LTS) interneurons. They show that their modelled connections capture the experimental evidence for physiological interactions between the two neuronal populations, and mimic findings on the muscarinic (M4) and nitric oxide modulation of LTS and cholinergic interneurons respectively (Frost Nylen et al, 2020). The next two articles focus on the function of the parvalbumin-containing, fastspiking, striatal GABAergic interneurons.…”

Section: E D I T O R I a L Special Issue Editorial: Basal Ganglia/movement Disordersmentioning

confidence: 65%