2003
DOI: 10.1152/jn.00932.2002
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Reciprocal Interactions Between Calcium and Chloride in Rod Photoreceptors

Abstract: (Bader et al. 1982). In cones, the current flux through I Cl(Ca) is at least eightfold greater than the current through I Ca (Barnes and Hille 1989). The chloride equilibrium potential (E Cl ) of salamander rods is about -20 mV . In olfactory receptors, E Cl is also positive to the cell's resting potential and acts to boost the receptor potential (Kleene and Gesteland 1991). In rods, depolarizing responses to darkness would also presumably be boosted by activation of I Cl(Ca) . In addition, activation of I Cl(… Show more

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Cited by 42 publications
(47 citation statements)
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“…In contrast, the Cl − efflux which accompanies activation of I Cl(Ca) depletes intracellular Cl − and thus inhibits I Ca through direct effects of Cl − on Ca 2+ channel open probability . In support of such a feedback relationship between I Ca and I Cl(Ca) (Thoreson et al, 2003a). In cones, E Cl appears to be near or slightly below the dark resting potential (Kaneko and Tachibana, 1986;Thoreson and Burkhardt, 1991;Kraaij et al, 2000;Thoreson and Bryson, 2005), whereas in rods it is 25 mV positive to the dark resting potential .…”
Section: Ionic Modulation Of Calcium Channels: Chloride-reducing the mentioning
confidence: 89%
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“…In contrast, the Cl − efflux which accompanies activation of I Cl(Ca) depletes intracellular Cl − and thus inhibits I Ca through direct effects of Cl − on Ca 2+ channel open probability . In support of such a feedback relationship between I Ca and I Cl(Ca) (Thoreson et al, 2003a). In cones, E Cl appears to be near or slightly below the dark resting potential (Kaneko and Tachibana, 1986;Thoreson and Burkhardt, 1991;Kraaij et al, 2000;Thoreson and Bryson, 2005), whereas in rods it is 25 mV positive to the dark resting potential .…”
Section: Ionic Modulation Of Calcium Channels: Chloride-reducing the mentioning
confidence: 89%
“…4 which shows the change in I Ca from rod photoreceptors recorded when using a rod voltage response to light as the command waveform. At a dark potential of −44 mV in salamander rods, I Ca attains <20% of its peak activity (Thoreson et al, 2003a). The probability that calcium channels remain open diminishes as the membrane hyperpolarizes in response to light and I Ca becomes vanishingly small as the membrane potential passes below −55 mV.…”
Section: Relationship Between Membrane Potential and Calcium Influxmentioning
confidence: 99%
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