2011
DOI: 10.1016/j.jpain.2011.03.003
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Reciprocal Relationship Between Pain and Depression: A 12-Month Longitudinal Analysis in Primary Care

Abstract: Pain and depression are the most prevalent physical and psychological symptom-based disorders, respectively, and co-occur 30–50% of the time. However, their reciprocal relationship and potentially causative effects on one another have been inadequately studied. Longitudinal data analysis involving 500 primary care patients with persistent back, hip or knee pain were enrolled in the Stepped Care for Affective Disorders and Musculoskeletal Pain (SCAMP) study. Half of the participants had comorbid depression and … Show more

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Cited by 477 publications
(415 citation statements)
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“…Pain is associated generally with increased risk of depression (Kroenke et al . 2011) and breastfeeding pain has been associated with increased risk of PND (Watkins et al . 2011).…”
Section: Discussionmentioning
confidence: 99%
“…Pain is associated generally with increased risk of depression (Kroenke et al . 2011) and breastfeeding pain has been associated with increased risk of PND (Watkins et al . 2011).…”
Section: Discussionmentioning
confidence: 99%
“…In a longitudinal study on 500 patients with persistent pain, pain and depression had strong and similar effects on one another over a 12-month period [26]. There is substantial evidence that the substantial variation in symptom intensity and magnitude of disability for a given pathophysiology is best explained by psychological and sociological factors.…”
Section: Discussionmentioning
confidence: 99%
“…Although this study's cross-sectional design precludes causal inferences, one plausible interpretation of these data is that the presence of posttraumatic stress symptoms amplifies the experience of chronic pain, and/or perhaps vice versa. A recent longitudinal study uncovered the complex nature of depression and chronic pain, detailing how the two reciprocally serve to exacerbate and maintain one another [58]. It would be logical to suppose that PTSD and chronic pain may follow a similar pattern.…”
Section: Outcalt Et Al Veterans With Comorbid Chronic Pain and Ptsdmentioning
confidence: 99%