Reciprocating Reentry

Asirvatham, Samuel J.; Stevenson, William G.

doi:10.1161/circep.115.003241

Cited by 1 publication

(6 citation statements)

References 3 publications

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“…These tachycardias were simulated by blocking certain electrical pathways, and we demonstrated that they could be eliminated through simulated ablation, further adding to our understanding of the underlying mechanisms of arrhythmias. 10,16,17 The two-dimensional model was a critical step in advancing our understanding of arrhythmias.…”

Section: Resultsmentioning

confidence: 99%

“…This was achieved through a combination of published research and our own experimentation. 2,3,9,10,30,43 With the ability to create a functioning three-dimensional model, we were then able to perform simulations of selected node ablations in order to eliminate the chaotic behavior and restore sinus rhythm. This demonstrated the potential of the model to provide insights into the mechanisms underlying AF and make informed decisions on the development of effective therapies.…”

Section: Three-dimensional Modelmentioning

confidence: 99%

“…2,5,8,9 There are two basic mechanisms of action that can cause SVT. 2,10,11 The simplest of the two is focal tachycardia. Focal tachycardias are caused by increased automaticity in specific regions of the heart overriding the sinus node, causing the entire heart to mistakenly follow its lead.…”

Section: Introductionmentioning

confidence: 99%

“…3,10,[14][15][16][17] While many forms of reentry can be explained by anomalous anatomical features such as extra electrical connections between what should be electrically isolated areas of the heart, other circuits remain poorly understood or can result from previous ablation lesions. 10,11,16,17 AF, which many experts feel should be in a category of its own, is the least understood of the tachycardias and most prevalent in patients. 1,5,15,18 AF is a chaotic arrhythmia that takes over the heart.…”

Section: Introductionmentioning

confidence: 99%

“…Reentrant tachycardias involve intricate multivariate feedback loops that can be unique to individual anatomy and local electrical properties. 3,10,14–17 While many forms of reentry can be explained by anomalous anatomical features such as extra electrical connections between what should be electrically isolated areas of the heart, other circuits remain poorly understood or can result from previous ablation lesions. 10,11,16,17 AF, which many experts feel should be in a category of its own, is the least understood of the tachycardias and most prevalent in patients.…”

Section: Introductionmentioning

confidence: 99%

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Modeling Supraventricular Tachycardia Using Dynamic Computer-Generated Left Atrium

Wyatt

Campbell

McIntosh

et al. 2023

Preprint

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Supraventricular Tachycardia (SVT) is a type of irregular heartbeat seen when the heart's upper chambers beat either too quickly or out of rhythm with the heart's lower chambers. The loss of synchronization between the upper and lower chambers will result in perturbations of, blood flow. This is why SVT, which includes atrial fibrillation and atrial flutter, is a leading cause of strokes, heart attacks, and heart failure in the world today. The most successful treatment for SVT is catheter ablation, a procedure in which an electrophysiologist (EP) maps the heart to find areas with abnormal electrical activity. The EP then runs a catheter into the heart to ablate the abnormal areas, blocking the electrical signals or destroying the myocytes causing them. Not much is known about what triggers SVT and much research is still being done to find effective ablation strategies for various forms of SVT. We have produced a dynamic model of the left atrium accelerated on NVIDIA GPUs. An interface allows researchers to insert ectopic signals into the simulated atrium and ablate sections of the atrium allowing them to rapidly gain insight into what causes SVT and how to terminate them.

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Section: Resultsmentioning

confidence: 99%