This article assesses the link between asymmetric information and transaction cost and how this can enhance or hinder female business owners from attaining entrepreneurial sustainability transitions in the Nigerian business space. The concept of information dissemination, business environment, and ease of doing business were scrutinized as a subdivision of asymmetric information and transaction cost theory among female entrepreneurs in Nigeria using the Enterprise Survey Data of the World Bank. Key indicators like regulations and taxes, gender, firm characteristics, finance, and infrastructure were highlighted as major business obstacles limiting female entrepreneurs. These were found to limit female entrepreneurs in accessing information, which can help them adequately flourish in the Nigerian business environment, as well as the attainment of entrepreneurial sustainability transitions.