Recognition and clinical implications of high prevalence of migraine in patients with Brugada syndrome and drug‐induced type 1 Brugada pattern

Hasdemir, Can; Gökçay, Figen; Orman, Mehmet; Kocabaş, Umut; Payzın, Serdar; Şahin, Hatice; Nyholt, Dale R.; Antzelevitch, Charles

doi:10.1111/jce.14778

Cited by 3 publications

(2 citation statements)

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“…It has a complex transmission pattern with incomplete penetrance, involving autosomal dominant inheritance in most cases, and autosomal recessive or X-linked inheritance in a few patients (5,6). BrS planetwide prevalence is estimated to be 1-16 per 10,000, but the true prevalence is difficult to estimate due to the dynamic electrocardiographic pattern and normal sign during the examination, incomplete penetrance, variable expressivity, and problematic diagnosis (7)(8)(9)(10). The characteristic BrS electrocardiogram (ECG) can be classified into three types, referring to various ST-segment and T-wave morphologies in the precordial leads (V1-V3).…”

Section: Introductionmentioning

confidence: 99%

“…Out of the three patterns in ECG, types 2 and 3 can convert to type 1 under the induction of sodium channel blockers, and only type 1 is diagnostic for BrS (11)(12)(13). Patients with BrS can have unexplained recurrent syncope, migraine, seizures, sleep disturbance, nocturnal agonal respiration, self-terminating polymorphic ventricular tachycardia, ventricular fibrillation (VF), inducibility of ventricular tachycardia with programmed electrical stimulation, and atrial arrhythmia, with a type 1 ECG pattern and sudden cardiac death (SCD) in family members (9,10,14,15). Other cardiac conduction disorders, such as atrioventricular block and right bundle branch block (RBBB) can be accompanied, spontaneously occurred, or induced by drug or other factors (5,8).…”

Section: Introductionmentioning

confidence: 99%

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Novel SCN5A and GPD1L Variants Identified in Two Unrelated Han-Chinese Patients With Clinically Suspected Brugada Syndrome

Yuan

Guo

Hong

et al. 2021

Front. Cardiovasc. Med.

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Brugada syndrome (BrS) is a complexly genetically patterned, rare, malignant, life-threatening arrhythmia disorder. It is autosomal dominant in most cases and characterized by identifiable electrocardiographic patterns, recurrent syncope, nocturnal agonal respiration, and other symptoms, including sudden cardiac death. Over the last 2 decades, a great number of variants have been identified in more than 36 pathogenic or susceptibility genes associated with BrS. The present study used the combined method of whole exome sequencing and Sanger sequencing to identify pathogenic variants in two unrelated Han-Chinese patients with clinically suspected BrS. Minigene splicing assay was used to evaluate the effects of the splicing variant. A novel heterozygous splicing variant c.2437-2A>C in the sodium voltage-gated channel alpha subunit 5 gene (SCN5A) and a novel heterozygous missense variant c.161A>T [p.(Asp54Val)] in the glycerol-3-phosphate dehydrogenase 1 like gene (GPD1L) were identified in these two patients with BrS-1 and possible BrS-2, respectively. Minigene splicing assay indicated the deletion of 15 and 141 nucleotides in exon 16, resulting in critical amino acid deletions. These findings expand the variant spectrum of SCN5A and GPD1L, which can be beneficial to genetic counseling and prenatal diagnosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel SCN5A and GPD1L Variants Identified in Two Unrelated Han-Chinese Patients With Clinically Suspected Brugada Syndrome

Yuan

Guo

Hong

et al. 2021

Front. Cardiovasc. Med.

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Frequency of Irritable Bowel Syndrome in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Pattern

Sarica

Bor

Orman

et al. 2021

The American Journal of Cardiology

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Recent Developments in Vestibular Migraine: A Narrative Review

2023

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Purpose: The aim of this study was to review current literature regarding the epidemiology of vestibular migraine (VM), patient presentation, pathogenesis, and treatment. Recent Findings: VM is becoming an increasingly recognized condition in the United States, currently affecting 2.7% of people. Patients may experience vestibular symptoms, such as vertigo and imbalance, with or without other migrainous symptoms. Recent evidence has also shown that patients with VM are at higher risk for cochlear dysfunction, such as sudden deafness, sensorineural hearing loss, and tinnitus. The heritability and genetics are not well understood, and the pathogenesis may involve calcitonin gene-related peptide, which is also implicated in migraine headaches. A disease-specific patient reported outcome measure, the Vestibular Migraine Patient Assessment Tool and Handicap Inventory, was recently developed and validated. A limited number of controlled trials have assessed various therapies for VM, including triptans and beta-blockers. More data are needed to understand whether or not currently available migraine treatments are effective for VM. Summary: VM is a common etiology of vertigo and dizziness, presenting with a characteristic spectrum of symptoms. Early data suggest that migraine treatments may be helpful in some cases.

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Recognition and clinical implications of high prevalence of migraine in patients with Brugada syndrome and drug‐induced type 1 Brugada pattern

Cited by 3 publications

References 23 publications

Novel SCN5A and GPD1L Variants Identified in Two Unrelated Han-Chinese Patients With Clinically Suspected Brugada Syndrome

Novel SCN5A and GPD1L Variants Identified in Two Unrelated Han-Chinese Patients With Clinically Suspected Brugada Syndrome

Frequency of Irritable Bowel Syndrome in Patients with Brugada Syndrome and Drug-Induced Type 1 Brugada Pattern

Recent Developments in Vestibular Migraine: A Narrative Review

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