Recognition and management of depression in early psychosis

Bashir, Zainab; Griffiths, Siân Lowri; Upthegrove, Rachel

doi:10.1192/bjb.2021.15

Cited by 10 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the established relationship between psychosis, depression, and poor recovery outcomes, the diagnosis and management of this comorbidity presents a continued problem for clinicians, with a reported rate of misdiagnosis of over 27% [49,50]. Moreover, there are no large-scale controlled trials investigating the effectiveness of adjunctive antidepressants, or CBT, to specifically target depression within psychosis [14,51,52].…”

Section: Diagnostic Uncertainty and Comorbiditymentioning

confidence: 99%

See 1 more Smart Citation

Heterogeneity in treatment outcomes and incomplete recovery in first episode psychosis: does one size fit all?

et al. 2022

Self Cite

View full text Add to dashboard Cite

The heterogeneity in recovery outcomes for individuals with First Episode Psychosis (FEP) calls for a strong evidence base to inform practice at an individual level. Between 19–89% of young people with FEP have an incomplete recovery despite gold-standard evidence-based treatments, suggesting current service models, which adopt a ‘one-size fits all’ approach, may not be addressing the needs of many young people with psychosis. The lack of consistent terminology to define key concepts such as recovery and treatment resistance, the multidimensional nature of these concepts, and common comorbid symptoms are some of the challenges faced by the field in delineating heterogeneity in recovery outcomes. The lack of robust markers for incomplete recovery also results in potential delay in delivering prompt, and effective treatments to individuals at greatest risk. There is a clear need to adopt a stratified approach to care where interventions are targeted at subgroups of patients, and ultimately at the individual level. Novel machine learning, using large, representative data from a range of modalities, may aid in the parsing of heterogeneity, and provide greater precision and sophistication in identifying those on a pathway to incomplete recovery.

show abstract

Section: Diagnostic Uncertainty and Comorbiditymentioning

confidence: 99%

“…Moreover, there are no large-scale controlled trials investigating the effectiveness of adjunctive antidepressants, or CBT, to specifically target depression within psychosis [14,51,52]. Improved recognition and management of depression to improve recovery within EIS is needed [49].…”

Section: Diagnostic Uncertainty and Comorbiditymentioning

confidence: 99%

Heterogeneity in treatment outcomes and incomplete recovery in first episode psychosis: does one size fit all?

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…16 Besides, recent studies have revealed that early intervention in the high-risk of psychosis may prevent and/or delay the onset of psychosis. [17][18][19] Such progression has emphasized the importance of early identification of high-risk groups in community samples, which can lead to early intervention before the transition to clinical psychosis, improving the prognosis of patients with psychotic disorders.…”

Section: Introductionmentioning

confidence: 99%

“…The Diagnostic and Statistical Manual of Mental Disorders, 5th edition also included “attenuated psychosis syndrome,” as a condition requiring further study as a means of minimizing duration untreated psychosis and promoting better outcomes in treating psychotic disorders [ 16 ]. Besides, recent studies have revealed that early intervention in the high-risk of psychosis may prevent and/or delay the onset of psychosis [ 17 - 19 ]. Such progression has emphasized the importance of early identification of high-risk groups in community samples, which can lead to early intervention before the transition to clinical psychosis, improving the prognosis of patients with psychotic disorders.…”

Section: Introductionmentioning

confidence: 99%

Validation of the Korean Version of the Community Assessment of Psychic Experiences in General Population

Sim

Kim

Jung

et al. 2023

Psychiatry Investig

View full text Add to dashboard Cite

Objective The Community Assessment of Psychic Experiences has been widely translated and commonly used as a measure for psychotic experiences and psychosis proneness in clinical and research environments worldwide. This study aimed to establish the psychometric properties (reliability and validity) and factor structure of a Korean version of the Community Assessment of Psychic Experiences (K-CAPE) in the general population.Methods A total of 1,467 healthy participants completed K-CAPE and other psychiatric symptom-related scales (Paranoia scale, Patient Health Questionnaire-9, Dissociative Experiences Scale-II, and Oxford-Liverpool Inventory of Feelings and Experiences) via online survey. K-CAPE’s internal reliability was analyzed using Cronbach’s alpha coefficient. Confirmatory factor analysis (CFA) was performed to investigate whether the original three-factor model (positive, negative, and depressive) and other hypothesized multidimensional models (including positive and negative subfactors) were suitable for our data. Exploratory factor analysis (EFA) was conducted to explore better alternative factor solutions with a follow-up CFA. To assess convergent and discriminant validity, we examined correlations between KCAPE subscales with other established measures of psychiatric symptoms.Results K-CAPE showed good internal consistency in all original three subscales (all greater than α=0.827). The CFA demonstrated that the multidimensional models exhibited relatively better quality than the original three-dimensional model. Although the model fit indices did not reach their respective optimal thresholds, they were within an acceptable range. Results from the EFA indicated 3–5 factor solutions. In 3-factor solution, “negative-avolition” items were founded to be loaded more consistently with depressive items than with the negative dimension. In 4-factor solution, positive items were divided into two subfactors: “positive-bizarre experiences” and “positive-delusional thoughts,” while negative symptoms were separated into two distinct subfactors in 5-factor solution: “negative-avolition (expressive),” and “negative-social (experiential).” The correlation coefficients between K-CAPE subscales and corresponding measurements were significant (p<0.001), confirming the convergent and discriminant validity.Conclusion Our study provides evidence to support the reliability and validity of the K-CAPE and its use as a measure of psychotic symptoms in the Korean population. Although alternative factor structures did not improve the model fit, our EFA findings implicate the use of subfactors to investigate more specific domains of positive and negative symptoms. Given the heterogeneous nature of psychotic symptoms, this may be useful in capturing their different underlying mechanisms.

show abstract

“…This leads to either refusal of medical care or referral to primary care, in place of qualified mental health care [11]. Yet, depression in youth may be the first symptom of a variety of non-affective disorders, including schizophrenia spectrum disorders such as schizotypal disorder and the prodromal stage of schizophrenia [12,13]. In order to evaluate the influence of the side effects of the therapy on the daily performance, all participants were examined on the 48-item Likert UKU Side Effect Rating Scale [21].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Untreated Illness in Youth Depression: A Cross-Sectional Study

Омельченко

Migalina

Kaleda

2022

Consortium Psychiatricum

View full text Add to dashboard Cite

Introduction Currently, there are many studies on the effect of the duration of an untreated psychosis on the further course of the disease. In terms of the duration of the untreated illness (DUI) in depression, such studies are significantly less. However, the delay in starting treatment for depression has also been found to have a negative impact on subsequent treatment. Objective To determine the effect of DUI on the severity of symptoms during the first depressive episode in non-psychotic mental disorders in youth and the degree of their reduction during treatment. Material and methods Diagnosed 52 male in-patients (16-25 years) who were first hospitalized for a depression in non-psychotic mental disorders affective disorders (F31, F32, F33, F34), personality disorders (F60) and schizotypal disorder (F21). The duration of the DUI was 35.817.0 months. The patients were divided into two groups: 1 group (59.6%, n=31) with the DUI lasting more than 36 months, 2 group (40.4%, n=21) with the DUI lasting less than 36 months. HDRS, SOPS and SANS were used. The examination was conducted twice at the time of the patients admission to hospital and before discharge. Statistical analysis was carried out with Statistica 12. Results There was no difference in the severity of the clinical symptoms upon admission. However, there were some differences in the residual depressive symptoms on the HDRS scale (p=0.019), negative symptoms on the SOPS (p=0.069), symptoms of disorganization on the SOPS (p=0.091), the total score of the SOPS (p=0.069), negative symptoms Alogia on the SANS (p=0.083), Anhedonia Asociality of the SANS (p=0.058) and the total score on the SANS (p=0.093) at the time of discharge in the patients of 1 group. Conclusion The DUI affects the reduction of depressive, negative and disorganized symptoms of youth depression in non-psychotic mental disorders.

show abstract

Recognition and management of depression in early psychosis

Cited by 10 publications

References 24 publications

Heterogeneity in treatment outcomes and incomplete recovery in first episode psychosis: does one size fit all?

Heterogeneity in treatment outcomes and incomplete recovery in first episode psychosis: does one size fit all?

Validation of the Korean Version of the Community Assessment of Psychic Experiences in General Population

The Effect of Untreated Illness in Youth Depression: A Cross-Sectional Study

Contact Info

Product

Resources

About