Background: Open abdomen (OA) is a useful option for treatment strategy in many acute abdominal catastrophes. A number of temporary abdominal closure (TAC) methods are used with limited number of comparative studies. The present study was done to examine risk factors for failed delayed primary fascial closure (DPFC) and risk factors for mortality in patients treated with OA.Methods: This study was a multicenter retrospective analysis of the hospital records of all consecutive patients treated with OA during the years 2009-2016 at 5 tertiary referral hospitals and 3 secondary referral centers in Finland.Results: 676 patients treated with OA were included in the study. Vacuum-assisted closure with continuous mesh-mediated fascial traction (VACM) was the most popular TAC method used (N=398, 59%) followed by VAC (N=128, 19%), Bogota bag (N=128, 19%) and self-designed methods (N=22, 3%). In multivariate analysis enteroathmospheric fistula and the number of needed TAC changes increased the risk for failed DPFC (OR=8.9, 95%C.I. 6.2-12.8, P<.001 and OR=1.1, 95% CI, 1.0-1.3, P<.001, respectively). Instead VACM and ruptured abdominal aortic aneurysm as cause for OA both decreased the risk for failed DPFC (OR=0.1, 95%C.I. 0.0-0.3, P<.001 and OR=0.2, 95%C.I. 0.1-0.7, P = .012). The overall mortality rate was 30%. In multivariate analysis for mortality, multi organ dysfunction (OR=2.4, 95%C.I. 1.6-3.6, P<.001) and increasing age (OR=4.5, to report the outcomes. The primary outcome was to assess the risk factors for failed delayed primary fascial closure (DPFC) and the secondary outcome was to assess the risk factors for mortality. Based on these findings, a treatment recommendation or algorithm for OA will be designed for Finnish surgical units that are active in managing critical surgical patients.Based on previous knowledge our hypothesis was that temporary closure of OA with a negative pressure system combined to continuous fascial traction is superior in comparison with other methods in relation to primary fascial closure and survival.
MethodsThis study was a multicenter retrospective analysis of the hospital records of all the consecutive patients treated with OA during the years 2009-2016 at all 5 tertiary referral hospitals in Finland (aka tertiary referral centers; the university hospitals of Helsinki, Turku, Tampere, Oulu, and Kuopio) and 3 secondary referral centers (the central hospitals in Seinäjoki, Rovaniemi, and Pori).Patients treated with OA were harvested and identified from hospital databases according to procedure codes for laparostomy and temporary abdominal closure (TAC) change (JAH30 and JAH33). The inclusion criteria were 1) OA treatment during the chosen time period and 2) age 18 to 99 years. The only exclusion criterion was incomplete hospital records. The study protocol was approved by each separate institutional review board at each contributing center.