A very rare autoimmune condition of the peripheral nervous system is named as myasthenia gravis it enables antibodies to be created against acetylcholine nicotinic postsynaptic receptors at the myoneural junction. Case report: Here, we discussed the admission of a 2-year-old child to the paediatric critical care unit as a result of a myasthenia gravis in crisis. The child's symptoms were limited facial movements, ptosis, and trouble in chewing. Weakening of the oropharyngeal/respiratory muscles, exhaustion, and recurrent respiratory infection. A few testing were carried out on him, including the edrophoium-tensilon test, blood analysis (Hb), ACHR antibodies, and imaging examinations (CT, MRI, X-ray). Genetic analysis Sample: to NIMHANS Bangalore, India. Efficient execution of treatment purposes, both corticosteroids and cholinesterase inhibitors. The NG tube has been placed, the child is on Nil Per oral (NPO) until he recovers. If properly managed, contemporaneous medical issues have minimal effect on the underlying conditions.