Recognition of barbiturates in molecularly imprinted copolymers using multiple hydrogen bonding

Abstract

Barbiturate-selective copolymers were prepared using the molecular imprinting technique in combination with a functional monomer, 2,6-bis(acrylamido)pyridine, capable of multiple hydrogen bond formation with the barbiturate templates.

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

“…Barbiturates have been imprinted using a functional monomer (2,6-bis(acrylamido)pyridine) capable of establishing multiple hydrogen bonds with the template. [474][475][476] Similarly using a polymerizable valine as functional monomer for the imprinting of di-peptides showed that the best recognition was achieved by using a 2:1 functional monomer:template ratio.477 Lübke et al 478 imprinted ampicillin by designing and using two different electroneutral functional monomers capable of forming strong interactions with the carboxylic acid functionality and amine functionality of the template, and polymerizable aminopyrazole derivatives which bind to the -sheet structure of peptides have been proposed as stoichiometric non-covalent monomers for peptide imprinting. …”

Stoichiometric molecularly imprinted polymers for the recognition of anti-cancer pro-drug tegafur

“…Our previous work, as well as that of others' [12][13][14][15], has shown that polymerisable functional monomers with complementary donor-acceptor-donor (D-A-D) arrays result in highly selective imprinted polymers, capable of recognising the template substance even in the presence of strongly competing analytes. Thus, of the previously reported custom-made functional monomers, including polymerisable adenine, purine and pyrimidine derivatives, 2,6-bis(acrylamido)pyridine (BAAPy) has been shown to be the most successful receptor and was used in the extraction of riboflavin from highly complex samples, such as beer and milk [16,17].…”

Molecular imprinting technology: challenges and prospects for the future

“…One way to achieve this may be to employ multifunctional monomers/crosslinkers. 8,13 If isolated interaction points were to be employed individually in the presence of water, most likely no effect would be seen. Given the additive effect on binding strength exerted e.g., by ion-pairs, 96 the concerted action of several interaction points between the monomer and the imprint antigen may be of adequate strength to be maintained in water.…”

“…1 Thus, compounds such as drugs, [8][9][10][11][12][13] amino acids, [14][15][16] carbohydrates, [17][18][19][20][21][22] proteins, [23][24][25] nucleotide bases, 26 hormones, 27,28 pesticides, [29][30][31] and coenzymes, 32 have been used successfully for the preparation of selective recognition matrices. In addition to studies where the nature of the recognition events per se have been the major issue, several areas of application have been envisaged for imprinted matrices (Table 1), viz.…”