Recognition of early melanoma: a monocentric dermoscopy follow‐up study comparing <i>de novo</i> melanoma with nevus‐associated melanoma

Martínez, David Álvarez; Boehncke, Wolf‐Henning; Kaya, Gürkan; Merat, Rastine

doi:10.1111/ijd.13977

Cited by 12 publications

(6 citation statements)

References 30 publications

(96 reference statements)

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“…NAMs are melanomas with greater diameter than DNM . Concerning dermoscopy, the features more commonly found are negative network (the most specific criteria according to some authors), globules, peripheral streaks, atypical network, and regression structures (white or peppering) . Atypical vascularization, asymmetrical pigment blotches, and blue‐whitish veil are less likely to appear in NAM, as it happens in our work.…”

Section: Discussionsupporting

confidence: 65%

Nevus‐associated melanoma: An observational retrospective study of 22 patients evaluated with dermoscopy and reflectance confocal microscopy

Franco

Villegas

Muruzábal

et al. 2019

Skin Research and Technology

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The frequency of nevus-associated melanoma (NAM) is widely variable among different reports. Recently, it has been estimated to be around 29% of all diagnosed melanomas. 1,2 The aim of this observational retrospective study was to analyze dermoscopic, reflectance confocal microscopy (RCM), and histologic features of a case series of 22 NAM. 2 | MATERIAL AND ME THODS We retrospectively reviewed a database recording the melanomas diagnosed in the Pathology Unit of Alcorcon Foundation Hospital between September 2011 and 2018, obtaining a total of 240 melanomas. In 45 of them (18.75%), an associated nevus was found, and we selected for the study 22 cases with good quality dermoscopic

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Section: Discussionsupporting

confidence: 65%

Nevus‐associated melanoma: An observational retrospective study of 22 patients evaluated with dermoscopy and reflectance confocal microscopy

Franco

Villegas

Muruzábal

et al. 2019

Skin Research and Technology

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“…Notably, we found that melanomas from patients who carry genetic variants protective for melanoma risk exhibit tumors with regression structures, shiny white structures, pigment network, and microerosions, which are dermoscopic features more prevalent in DNMMs and in more invasive melanomas with a worse prognosis (Alvarez Martinez et al., 2018; Deinlein et al, 2017; Silva et al., 2013). Interestingly, blue‐whitish veil has been previously associated with DNMMs (Shitara, Nascimento, et al, 2015), and shiny white structures with thicker or more invasive melanomas (De Giorgi & Carli, 2002; Deinlein et al, 2017; Ribero et al., 2016).…”

Section: Discussionmentioning

confidence: 98%

“…Melanoma is a cutaneous neoplasm originated from melanocytes, but its origin has always been a controversial subject (Bevona et al., 2003; Shitara, Tell‐Martí, et al, 2015; Thomas & Groben, 2004). Although most melanomas arise de novo, without contiguity with any pre‐existing nevus, pathology‐based studies have found that 20%–30% of melanomas arise from a pre‐existing melanocytic nevus (Alvarez Martinez et al., 2018; Cymerman et al, 2016). De novo melanomas (DNMMs) arise in a context related to a low nevus count (<50 nevi), while nevus‐associated melanomas (NAMMs) are more prevalent in patients with a high nevus count (>50 nevi; Haenssle et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

“…De novo melanomas (DNMMs) arise in a context related to a low nevus count (<50 nevi), while nevus‐associated melanomas (NAMMs) are more prevalent in patients with a high nevus count (>50 nevi; Haenssle et al., 2016). Clinical, dermoscopic and histopathological characteristics have been described for each subtype of melanomas (DNMMs and NAMMs; Alvarez Martinez et al., 2018; Martin‐Gorgojo et al, 2018; Pandeya et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

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Influence of germline genetic variants on dermoscopic features of melanoma

Pozzobon

Tell‐Martí

Calbet-Llopart

et al. 2021

Pigment Cell Melanoma Res

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Nevus count is highly determined by inherited variants and has been associated with the origin of melanoma. De novo melanomas (DNMMs) are more prevalent in patients with a low nevus count and have distinctive dermoscopic features than nevus‐associated melanomas. We evaluated the impact of nine single nucleotide polymorphisms (SNPs) of MTAP (rs10811629, rs2218220, rs7023329 and rs751173), PLA2G6 (rs132985 and rs2284063), IRF4 (rs12203592), and PAX3 (rs10180903 and rs7600206) genes associated with nevus count and melanoma susceptibility, and the MC1R variants on dermoscopic features of 371 melanomas from 310 patients. All MTAP variants associated with a low nevus count were associated with regression structures (peppering and mixed regression), blue‐whitish veil, shiny white structures, and pigment network. SNPs of PLA2G6 (rs132985), PAX3 (rs7600206), and IRF4 (rs12203592) genes were also associated with either shiny white structures or mixed regression (all corrected p‐values ≤ .06). Melanomas from red hair color MC1R variants carriers showed lower total dermoscopy score (p‐value = .015) and less blotches than melanomas from non‐carriers (p‐value = .048). Our results provide evidence that germline variants protective for melanoma risk and/or associated with a low nevus count are associated with certain dermoscopic features, more characteristic of de novo and worse prognosis melanomas.

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“…The reported dermoscopic features of NAM compared to de novo melanoma vary across studies and are presented in Table 3 52–56 . However, only two studies included a larger number of NAMs 52,55 .…”

Section: Dermoscopic Findings Of Nam Compared To De Novo Melanomamentioning

confidence: 99%

A review of nevus‐associated melanoma: What is the evidence?

Dessinioti

Geller

Stratigos

2022

Acad Dermatol Venereol

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Cutaneous melanoma may have an adjacent nevus remnant on histological examination in 30% of cases (nevusassociated melanoma, NAM), while it may appear de novo, without a precursor lesion, in the remaining 70% of cases.Nevus-associated melanoma and the concept of acquired melanocytic nevi serving as precursors of melanoma has long been considered as a controversial topic. This controversy is, in part, due to their overall low rate of transformation to melanoma and scarce data on the natural history of progression. Another matter of debate regarded the possibility that the reported differences in NAM vs. de novo melanoma were due to an underestimation of NAM in thicker lesions due to obliteration of the nevus component by the tumour. During the last few years, several evidence has accumulated in order to address these controversies. In this review, we present a comprehensive synthesis of the epidemiological, clinical, dermoscopic and genetic findings in NAM, including thin NAM, compared to de novo melanoma. Answering the questions on nevus-associated melanoma may provide further insight into the classification of these tumours and disentangle their biology and route of development from that of de novo melanoma.

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Recognition of early melanoma: a monocentric dermoscopy follow‐up study comparing de novo melanoma with nevus‐associated melanoma

Cited by 12 publications

References 30 publications

Nevus‐associated melanoma: An observational retrospective study of 22 patients evaluated with dermoscopy and reflectance confocal microscopy

Nevus‐associated melanoma: An observational retrospective study of 22 patients evaluated with dermoscopy and reflectance confocal microscopy

Influence of germline genetic variants on dermoscopic features of melanoma

A review of nevus‐associated melanoma: What is the evidence?

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