The Central Red Sea Rift is a natural laboratory to study the transition from rifting to spreading. Based on new reflection seismic profiles and gravity modeling, we examined the crustal structure, tectonic evolution, breakup mechanism, and future evolution of the Central Red Sea Rift. Along this rift axis, the breakup of continental lithosphere is discontinuous and the oceanic crust is limited to the axial deeps. The punctiform breakup and formation of deeps is assisted by mantle upwelling and topographic uplift, but the nucleation is directly controlled by the normal-fault system. The discontinuities spaced between axial deeps within the relatively continuous central troughs are presently axial domes or highs and will evolve into new deeps with tectonic subsidence. Isolated deeps will grow and connect with each other to become a continuous central trough, before transitioning into a unified spreading center.