Recognition of greater diversity of Bacillus species and related bacteria in human faeces

Hoyles, Lesley; Honda, Harue; Logan, Niall A.; Halket, Gillian; Ragione, Roberto M. La; McCartney, Anne L.

doi:10.1016/j.resmic.2011.10.004

Cited by 56 publications

(33 citation statements)

References 48 publications

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“…The awareness that the complex communities of microbes that reside the human body play a critical role in the health of the host has led to a number of researches [25-27]. One of the key functions that have been attributed to the gut microbiota concerns the metabolic functions carried out by this community [28].…”

Section: Discussionmentioning

confidence: 99%

“…Further verification of the lack of antibiotic resistance transfer in intestinal pathogenic bacteria trough additional investigation on the genetic bases of some resistances traits are needed, because so far a clear resistance mechanism has not been identified and the presence of mobile genetic elements cannot be completely ruled out. But interestingly, recent findings show that Bacillus species, can be readily isolated from human faeces and frequently these include B. clausii strains with high similarity to the wild type strain DSM8716 [26, 27]. In this study, we highlighted the similarity of phenotypic resistance patterns of the four probiotic strains with the type strain DSM8716, and then it is reasonable to suggest that B. clausii , naturally bearing several resistance traits, is not uncommon in the natural commensal flora.…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic Sensitivity of Bacillus clausii Strains in Commercial Preparation

Abbrescia¹,

Palese²,

Papa³

et al. 2015

CIEMD

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Recently has been acknowledged the healthy use of Bacillus and related bacteria as probiotics. A mixture reported to contain four probiotic strains of Bacillus clausii is marketed as an OTC (Over The Counter) medicinal supplement for human use. Their poliantibiotic resistant property, useful for restoring the gut microbiota during antibiotic treatment, raises the question about the risk of resistance transfer. In order to better assess the risk-benefit ratio it is important to always monitoring the pattern and stability of resistance spectra in these bacteria. In this work, we have extensively redefined the antibiotic susceptibility profile of these four probiotic strains. Resistance phenotype has been determined by screening a large number of antibiotics, including natural products (such as penicillin, vancomycin and erythromycin), and completely synthetic molecules (such as fluoroquinolones). Extensive comparison with a wild type strain belonging to the normal intestinal microbiome was carried out. The molecular basis of some resistances was determined. Observed antibiotic resistances were correlated with previous and new data in safety evaluations of these strains for human use.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antibiotic Sensitivity of Bacillus clausii Strains in Commercial Preparation

Abbrescia¹,

Palese²,

Papa³

et al. 2015

CIEMD

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show abstract

“…Some Bifidobacterium species are critical to the health of the gut and are now considered as essential constituents of the probiotics used in the treatment of inflammatory bowel disease with no obvious side effects (Ghouri et al, 2014). In contrast to Bifidobacteriales species, the Actinomycetales species, despite being a highly diverse group of bacteria, have a relatively low abundance in healthy human gut: (10 2 –10 3 ) cells/g of fecal sample (Hoyles et al, 2012). Amongst most detected genera are Corynebacterium and Propionibacterium (Eggerth, 1935; Moore and Holdeman, 1974; Holdeman et al, 1976).…”

Section: Identity Of Microbes Colonizing Human Gutmentioning

confidence: 99%

Significance of Microbiota in Obesity and Metabolic Diseases and the Modulatory Potential by Medicinal Plant and Food Ingredients

Eid

Wright

et al. 2017

Front. Pharmacol.

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Metabolic syndrome is a cluster of three or more metabolic disorders including insulin resistance, obesity, and hyperlipidemia. Obesity has become the epidemic of the twenty-first century with more than 1.6 billion overweight adults. Due to the strong connection between obesity and type 2 diabetes, obesity has received wide attention with subsequent coining of the term “diabesity.” Recent studies have identified unique contributions of the immensely diverse gut microbiota in the pathogenesis of obesity and diabetes. Several mechanisms have been proposed including altered glucose and fatty acid metabolism, hepatic fatty acid storage, and modulation of glucagon-like peptide (GLP)-1. Importantly, the relationship between unhealthy diet and a modified gut microbiota composition observed in diabetic or obese subjects has been recognized. Similarly, the role of diet rich in polyphenols and plant polysaccharides in modulating gut bacteria and its impact on diabetes and obesity have been the subject of investigation by several research groups. Gut microbiota are also responsible for the extensive metabolism of polyphenols thus modulating their biological activities. The aim of this review is to shed light on the composition of gut microbes, their health importance and how they can contribute to diseases as well as their modulation by polyphenols and polysaccharides to control obesity and diabetes. In addition, the role of microbiota in improving the oral bioavailability of polyphenols and hence in shaping their antidiabetic and antiobesity activities will be discussed.

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“…; Hoyles et al . ) and should be considered gut commensals rather than solely soil micro‐organisms (Hong et al . ).…”

Section: Introductionmentioning

confidence: 99%

Survival and persistence of Bacillus clausii in the human gastrointestinal tract following oral administration as spore-based probiotic formulation

et al. 2015

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Recognition of greater diversity of Bacillus species and related bacteria in human faeces

Cited by 56 publications

References 48 publications

Antibiotic Sensitivity of Bacillus clausii Strains in Commercial Preparation

Antibiotic Sensitivity of Bacillus clausii Strains in Commercial Preparation

Significance of Microbiota in Obesity and Metabolic Diseases and the Modulatory Potential by Medicinal Plant and Food Ingredients

Survival and persistence of Bacillus clausii in the human gastrointestinal tract following oral administration as spore-based probiotic formulation

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