Recognition of Hg2+ ion in an organic semi-aqueous medium by a new napthalimide based fluorescent probe and its bioimaging applications

Jothi, Dhanapal; Iyer, Sathiyanarayanan Kulathu

doi:10.1016/j.inoche.2022.109735

Cited by 12 publications

(6 citation statements)

References 36 publications

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“…Moreover, the chemosensor was efficiently applied for bioimaging Hg 2 + ions in the liver cells of Escherichia coli. [89] Panchenko et al while the presence of two bands was observed when excited at 375 nm which could be attributed to the excitation of both the chromophores. The addition of Hg 2 + didn't result in an appreciable change in the absorption spectra but the chromophore emission was augmented by two folds which could be the result of the inhibition of the PET process.…”

Section: Detection Of Mercury (Hg 2 + ) Ionsmentioning

confidence: 92%

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1,8‐Naphthalimide‐Based Chemosensors: A Promising Strategy for Detection of Metal Ions in Environmental and Biological Systems

Kaur,

Singh,

Tandon

et al. 2023

ChemistrySelect

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The advancement of optical chemosensors has achieved success with the advent of Supramolecular Chemistry. Unlike other scaffolds, the 1,8‐naphthalimide motif has emerged as an excellent fluorescent chemosensor due to its photophysical properties like thermostability, cytotoxicity, membrane permeability, selectivity, and sensitivity. The naphthalimide scaffold is distinctive in its ways of tracking biological analytes and diagnosing its role in various diseases. This review provides insight into current developments in the synthesis and designing of 1,8‐naphthalimide‐based chemosensors for the recognition of metal ions, its mechanistic approach for its sensitivity, selectivity, and practical applications in a real environment. We hope that this review will aid to develop a novel approach to sense toxic analytes in real water samples and improve real‐time applications.

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Section: Detection Of Mercury (Hg 2 + ) Ionsmentioning

confidence: 92%

“…The detection limit of 29 for Hg 2+ was found to be 3.3 nM with association constant of 3.429×10 6 M −1 . Moreover, the chemosensor was efficiently applied for bioimaging Hg 2+ ions in the liver cells of Escherichia coli [89] …”

Section: Probes For Detecting Metal Ionsmentioning

confidence: 99%

1,8‐Naphthalimide‐Based Chemosensors: A Promising Strategy for Detection of Metal Ions in Environmental and Biological Systems

Kaur,

Singh,

Tandon

et al. 2023

ChemistrySelect

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“…不仅如此, 硫代缩醛/缩酮的脱保护反应也常被用于设计 Hg 2 ＋探针 [138] . Hg 2 ＋可催化硫代缩醛/缩酮脱保护反应的进行, 常通过在萘酰亚胺 [139] 、三苯胺 [140] 、咔唑 [141] 等荧光团中引入二硫缩醛/缩酮部分作为 Hg 2 ＋的反应位点, 构建新型的 Hg 2 ＋探针 [142] .…”

Section: 二硫代缩醛/酮脱保护反应类断键型小分子探针unclassified

Research Progress in Mercury Ion Fluorescence Probes Based on Organic Small Molecules

Li,

Chen,

Chen

et al. 2023

Chinese Journal of Organic Chemistry

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Mercury has strong biological toxicity and poses great harm to human health and the environment. Fluorescent probes have been widely applied in the detection of mercury ion in recent years, due to these probes with high sensitivity, high selectivity, and real-time monitoring. Owing to the advantages of small molecules such as structural diversity, good repeatability, easy modification, and clear sensing mechanisms, many organic small molecular fluorescence probes for detecting mercury ion have also been developed. According to the different reaction mechanisms between probes and mercury ion, these organic small molecular fluorescence probes can be classified into two categories based on coordination type reactions and bond breaking type reactions. The research progress of organic small molecular fluorescence probes used to detect mercury ion in the past five years is summarized in detail. This provides a reference for their further development in the future, especially for the new turn-on type reactive organic small molecular fluorescence probes for detecting mercury ion by utilizing the characteristic reactions. Keywords mercury ion detection; fluorescent probes; organic small molecules; reaction mechanism; molecular design and synthesis 汞是一种剧毒的不可降解的金属污染物 [1] , 一旦进入生物体, 就会在生物体内累积, 影响蛋白质和酶的正常功能, 进而导致各种急性中毒事件 [2] . 因此, 建立一种灵敏、选择性检测汞离子的有效分析方法, 对汞离子的监测、临床诊断及治疗具有重要意义 [3] . 与用来检测汞离子的传统分析方法, 如伏安法、原子吸收光谱法、 X 射线吸收光谱法、分光光度法等相比, 荧光探针具有高选择性、响应速度快和可实时监测等优点 [4] . 这使得汞离子荧光探针引起了研究人员极大的关注, 并得到了高速发展 [5][6][7] .

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“…[31][32][33][34][35][36][37][38][39][40][41] However, these probes have limited solubility in water and cannot be used for sensing research in pure water, thereby limiting their applicability. [42][43][44][45][46] Therefore, the exploration of water-soluble probes is of great importance. In this regard, several watersoluble polymeric systems with thioacetal units in the side chain have recently been developed for sensing mercury in pure water media and have good biocompatibility for live cell imaging.…”

Section: Introductionmentioning

confidence: 99%

Pyrene‐Based “Turn‐On” Fluorescent Polymeric Probe with Thioacetal Units in the Main Chain for Mercury(II) Detection in Aqueous Solutions and Living Cells

Gu,

Li,

et al. 2024

Macromol. Rapid Commun.

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A water‐soluble polymeric pyrene‐based polythioacetal (PTA‐Py) with thioacetal units in the main chain is simply synthesized by direct polycondensation of 3, 6‐dioxa‐1, 8‐octanedithiol, 1‐pyrene formaldehyde, and mPEG2k‐SH. The probe PTA‐Py shows a good fluorescence response to Hg2+ ions due to the Hg2+‐promoted deprotection reaction of thioacetal groups to regenerate the original 1‐pyrene formaldehyde compound. After adding Hg2+ to the PTA‐Py solution, the fluorescence intensity (FI) gradually increases with increasing concentrations of Hg2+. Compared with other metal ions, the probe exhibits high sensitivity, good selectivity, and rapid response to Hg2+. The low detection limits are 12.3 nm in ethanol‐PBS buffer and 13.3 nm in water, respectively. The results imply that the simply synthesized water‐soluble polymeric probe had potential applications in the rapid detection of Hg2+ ions in aqueous solutions. Moreover, the polymeric PTA‐Py shows high sensitivity for CH3Hg+ with detection limits of 26.5 nm in ethanol/PBS buffer. In addition, PTA‐Py can efficiently detect Hg2+ ions in HeLa cells. The results demonstrate that a valuable method is developed for biocompatible polymeric sensors for Hg2+ ions in biological and environmental samples.

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Recognition of Hg2+ ion in an organic semi-aqueous medium by a new napthalimide based fluorescent probe and its bioimaging applications

Cited by 12 publications

References 36 publications

1,8‐Naphthalimide‐Based Chemosensors: A Promising Strategy for Detection of Metal Ions in Environmental and Biological Systems

1,8‐Naphthalimide‐Based Chemosensors: A Promising Strategy for Detection of Metal Ions in Environmental and Biological Systems

Research Progress in Mercury Ion Fluorescence Probes Based on Organic Small Molecules

Pyrene‐Based “Turn‐On” Fluorescent Polymeric Probe with Thioacetal Units in the Main Chain for Mercury(II) Detection in Aqueous Solutions and Living Cells

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