Objectives: To find the frequency and type of comorbid conditions in patients presenting with oral diseases. Study Design: Observational study. Setting: Department of Oral and Maxillofacial Surgery, University College of Dentistry, University of Lahore. Period: January 2018 to December 2019. Material & Methods: After approval from the ethical committee, all cases presenting with oral diseases to the oral and maxillofacial surgery department were recruited consecutively. A thorough history and relevant examinations were made. All the previous records of the patient, including laboratory tests and the medical summary, were reviewed for the existence of any comorbid conditions. The data was entered on the spreadsheet. Descriptive statistics were used. Frequencies and percentages were calculated for comorbid conditions. Results: This study included 17155 patients who visited the oral and maxillofacial surgery department for procedures related to oral surgery. Others patients presenting to other departments of dentistry were excluded. Out of these, 4056 patients (24%) had comorbid conditions. Among these patients, 77% had single comorbid condition and 23% had multiple systemic disease. The most common comorbid condition was hypertension (77%), followed by diabetes (33%) and hepatitis (11%). Conclusion: A high prevalence of comorbidities was found in our study. Hypertension, diabetes mellitus, and hepatitis C were the common comorbidities. In addition, a significant number of patients had multiple comorbidities.