“…[31][32][33][34] On the basis of the spirolactam/ring-opened amide equilibrium of rhodamine, several fluorescence-based sensing systems for metal ions have been developed to serve as a fluorescent chemosensor to detect metal ions, such as Hg 2+ , Cu 2+ , Al 3+ , Cr 3+ , Mg 2+ , and Fe 3+ . [35][36][37][38][39][40][41][42][43] However, to the best of our knowledge, rhodamine B-based fluorescent probes for GSH are still rare. [44] Herein, we report the synthesis and characterization of a new rhodamine B-derivatized fluorescent chemosensor based on a maleimide moiety ,namely N-(2-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen] -2-yl)ethyl)-3,5-bis(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzamide (Probe-M, Figure 1).…”