Recognition of Pyrene Using Molecularly Imprinted Electrochemically Deposited Poly(2‐mercaptobenzimidazole) or Poly(resorcinol) on Gold Electrodes

Abstract

The feasibility of using thiol chemistry to form molecularly imprinted polymer-coated gold electrodes to measure pyrene is reported. For the first approach, poly(2-mercaptobenzimidazole) (2-MBI) was electrochemically deposited on gold electrodes in the presence or absence of the template pyrene. For the second approach, the pyrene derivative N-(1-pyrenyl)maleimide was covalently bound to 1,3-propane thiol that had been previously self-assembled on a cleaned gold surface. Resorcinol was then electrochemically polymerized onto the electrode followed by electrochemical stripping of the thiolated pyrene from the polymer-coated electrode. For both electrode configurations, the binding of pyrene to the MIP-coated electrode was detected indirectly through pyrene-dependent access of a ferricyanide probe to the electrode surface as measured using square-wave voltammetry.

Electrochemically synthesized polymers in molecular imprinting for chemical sensing

“…As mentioned already, thiol chemistry appeared feasible to fabricate MIP-film-based chemosensors. Toward that, SAM-coated Au electrodes were devised for SWV determination of pyrene [ 186 ]. Actually, two different procedures were developed to prepare MIP films on Au electrodes.…”

Protein Rebinding to a Surface‐Confined Imprint

“…For a small molecule, a similar procedure has been proposed by Luo et al . 29 for the imprinting of thiol‐modified pyrene. The rebinding was characterized by measuring the access of a redox probe to the electrode surface.…”

Electrode Materials (Bulk Materials and Modification)

“…Molecularly imprinted polymers have been developed for the detection of small organic molecules relevant to environmental applications. These include pesticides, [537][538][539][540][541][542][543][544][545][546] polycyclic aromatic hydrocarbons, 547-549 industrial pollutants, 550 antibacterial agents 551 and drugs. [552][553][554][555][556][557][558][559] The target analyte is detected by pulsed voltammetry after an accumulation at open-circuit potential for up to 20 min.…”