Recognition of Simian Sarcoma Virus Antigen by Human Sera

Kurth, Reinhard; Gelderblom, H.; Huesgen, Adolfine; Katz, F; Seiler, F. R.; Steward, M. W.; Vettermann, W.

doi:10.1007/978-3-642-67057-2_50

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1979

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“…Secondly, age distribution studies suggest that the anti-gp70 SSAV response is at its peak in early childhood, i.e. when the lymphoreticular system develops and proliferates (Kurth et al, 1979). Provided the immunity we measure by using gp70 SSAV as antigen was originally triggered by a virus, one may conclude that such a virus is preferentially expressed in proliferating B lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Elevated titer of antibodies to simian sarcoma virus envelope antigen (gp70) and normal response to influenza virus in untreated danish Hodgkin's patients

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et al. 1979

Intl Journal of Cancer

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Untreated Danish Hodgkin's disease (HD) patients and paired age- and sex-matched controls were tested for serum antibodies to Epstein-Barr virus (EBV), six strains of influenza virus and Simian sarcoma virus/Simian sarcoma-associated virus [SSV(SSAV)] antigens. HD sera showed significantly elevated titers against EBV and both increased incidence and mean titer of antibodies to the envelope glycoprotein of SSV(SSAV), whereas testing against the influenza viruses revealed no differences between HD and controls. A focus reduction assay demonstrated a low incidence in HD and controls of sera with neutralizing effects against SSV(SSAV) and the "baboon" C-type virus component of the human HL-23 virus complex, which seemed coupled to HL-A type W19.

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Section: Discussionmentioning

confidence: 99%