2003
DOI: 10.1016/s0959-440x(03)00081-2
|View full text |Cite
|
Sign up to set email alerts
|

Recognition of the DNA minor groove by pyrrole-imidazole polyamides

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

9
578
0
4

Year Published

2007
2007
2018
2018

Publication Types

Select...
4
2
1

Relationship

0
7

Authors

Journals

citations
Cited by 609 publications
(591 citation statements)
references
References 78 publications
9
578
0
4
Order By: Relevance
“…[23][24][25][26] While several different binding motifs have been explored, the hairpin motif provides excellent affi nity and specifi city for DNA and can be accessed through a facile synthetic route. 23 In the hairpin motif, a γ-aminobutyric acid (γ) covalently links the carboxylic terminus of one polyamide with the amino terminus of the other.…”
Section: Hairpin Polyamide Motifmentioning
confidence: 99%
See 3 more Smart Citations
“…[23][24][25][26] While several different binding motifs have been explored, the hairpin motif provides excellent affi nity and specifi city for DNA and can be accessed through a facile synthetic route. 23 In the hairpin motif, a γ-aminobutyric acid (γ) covalently links the carboxylic terminus of one polyamide with the amino terminus of the other.…”
Section: Hairpin Polyamide Motifmentioning
confidence: 99%
“…15 Pyrrole-imidazole polyamides bind the minor groove of DNA in a sequence-specifi c manner at subnanomolar concentrations. 24,25 The empirically derived "pairing rules" allow for shape-selective recognition of DNA sequences. 24,25 Polyamides designed to target 5'-WTGCWW-3' are shown with their putative binding sites in the enhancers of Oct4 target genes ( Figure 5.2).…”
Section: Sox2mentioning
confidence: 99%
See 2 more Smart Citations
“…Diamidines have excellent transport properties into a variety of cells [3][4][5][6] and an orally available prodrug of the diamidine, DB75, furamidine (Figure 1), is currently in phase III clinical trials against trypanosomes, which cause sleeping sickness, as well as other microbial parasites. 4,[7][8][9][10][11] DB75 binds strongly in the minor groove of DNA and recognizes sequences of at least four AT base pairs. [7][8][9] For design of new agents that target additional disease organisms/cells as well as evading any possible resistance that could develop, we have focused on modifications of the structure, heterocycles, and properties of the basic units of the DB75 molecule.…”
Section: Introductionmentioning
confidence: 99%