Recognition of the product of a novel MHC TL region gene (27b) by a mouse γδ T cell receptor

Ito, Kouichi; Kaer, Luc Van; Bonneville, Marc; Hsu, Sang; Murphy, Donal B.; Tonegawa, Susumu

doi:10.1016/0092-8674(90)90019-b

Cited by 208 publications

(120 citation statements)

References 46 publications

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“…These degrees of similarity are substantially lower than those found among the MHC class I chains in any species. For example, the mouse nonclassical H-2T22 and H-2M3 chains share an average of 601% and 67% identity in their al-a3 domains with the H-2K class I chain, respectively (10,11 Comparison of MICA with other class I chains shows that most of the matching residues are common to all of the aligned sequences (Figs. 3 and 4).…”

Section: Vppmvnvtrseasegnitvtcrasgfypwnitlswrqdgvslshdtqqwgdvlpdgngtymentioning

confidence: 99%

“…These characteristics clearly distinguish the MIC gene family from the nonclassical mouse H-2Q, -T, and -M genes, which are organized in gene clusters that are segregated from the classical H-2K, -D, and -L genes (5)(6)(7)(8) and exist only in the mouse and perhaps some closely related rodents. However, it is peculiar that MICA and the T22b chain, which can be recognized by vd T cells (10), share a similar gap in the al domain (Fig. 3); the missing residues are normally associated with the "45" pocket (Fig.…”

Section: Vppmvnvtrseasegnitvtcrasgfypwnitlswrqdgvslshdtqqwgdvlpdgngtymentioning

confidence: 99%

“…In addition to the typical class I H-2K, -D, and -L genes, the mouse H-2 complex includes numerous of the nonclassical Q., T, and M genes (5)(6)(7)(8). Ofthese, some ofthe Tgenes encode ligands forT cells with yS antigen receptors (9,10) and the M3 gene product specifically presents N-formylated peptides of bacterial and mitochondrial origin (11,12). The human MHC contains within about 2 megabases six class I genes (13), of which HLA-A, -B, and -C encode the polymorphic antigen-presenting molecules (2).…”

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confidence: 99%

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A second lineage of mammalian major histocompatibility complex class I genes.

Bahram

Bresnahan

Geraghty

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

735

615

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Section: Vppmvnvtrseasegnitvtcrasgfypwnitlswrqdgvslshdtqqwgdvlpdgngtymentioning

confidence: 99%

Section: Vppmvnvtrseasegnitvtcrasgfypwnitlswrqdgvslshdtqqwgdvlpdgngtymentioning

confidence: 99%

mentioning

confidence: 99%

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A second lineage of mammalian major histocompatibility complex class I genes.

Bahram

Bresnahan

Geraghty

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

735

615

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show abstract

“…It seems to be evident, however, that T-cell receptor (Tcr) 3,6-positive T lymphocytes can recognize nonclassical class I antigens of the TL region (Haas et al 1990;Ito et al 1990), possibly induced by transformation and infection (Janeway et al 1988). The Q region of the AKR (H-2 k) mouse is comprised of six genes: Q1 k, Q2 k, Qfi, Q4 k, Q5 k, and QIO k with the Q5 gene being directly linked to the QIO gene (Weiss et al 1989).…”

Section: Introductionmentioning

confidence: 99%

Developmental and tissue-specific expression of the Q5 k gene

Schwemmle¹,

Bevec²,

Brem³

et al. 1991

Immunogenetics

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Abstract. Expression of the Q5 k gene was examined by northern blot analysis and polymerase chain reaction (PCR) in the AKR mouse and various cell lines, each of the H-2 ~ haplotype. Our results show that Q5 k mRNA is present during the whole postimplantational development of the AKR embryo/fetus (gestation day 6 to 15). In the juvenile mouse (week 2 to 4) transcription of the Q5 ~ gene persisted in all organs examined. In contrast, in the adult animal expression of the Q5 ~ gene was limited to the thymus and uterus of the pregnant mouse. Upon malignant transformation, the amount of Q5k-specific mRNA increased dramatically in thymus and could also be observed in the spleen of thymoma bearing animals. Expression of the Q5 k gene was also detectable in several transformed mouse cell lines. Mitogen stimulation or treatment with cytokines induced Q5 k expression in primary spleen cell cultures. A possible explanation for the tissue-restricted expression in the adult AKR mouse is discussed.

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“…3A). To distinguish whether TCR expression/signaling and/or development beyond the DN3 stage are required, we crossed ThPOK const RAG −/− mice to animals expressing the transgenic KN6 γδTCR, which recognizes the nonclassical MHC class I products T22 and T10 (32,33). On a β2m +/+ background, which supports ligand expression, KN6 thymocytes undergo development to the γδ T-cell lineage, as evidenced by progression to the DN4 stage and loss of expression of CD24, a marker of immaturity, whereas on a β2m −/− background, that lacks ligand expression, they undergo development to the DP stage, indicative of adoption of the αβ T-cell lineage (34,35).…”

Section: Thpok-mediated Lymphomagenesis Requires Dn-to-dp Developmentalmentioning

confidence: 99%

Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas

Lee

Xiao

Mookerjee‐Basu

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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The transcription factor T-helper-inducing POZ/Krueppel-like factor (ThPOK, encoded by the Zbtb7b gene) plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. Here we show that mice expressing a constitutive T-cell-specific ThPOK transgene (ThPOK const mice) develop thymic lymphomas. These tumors resemble human T-cell acute lymphoblastic leukemia (T-ALL), in that they predominantly exhibit activating Notch1 mutations. Lymphomagenesis is prevented if thymocyte development is arrested at the DN3 stage by recombination-activating gene (RAG) deficiency, but restored by introduction of a T-cell receptor (TCR) transgene or by a single injection of anti-αβTCR antibody into ThPOK const RAG-deficient mice, which promotes development to the CD4 + 8 + (DP) stage. Hence, TCR signals and/or traversal of the DN (double negative) > DP (double positive) checkpoint are required for ThPOK-mediated lymphomagenesis. These results demonstrate a novel link between ThPOK, TCR signaling, and lymphomagenesis. Finally, we present evidence that ectopic ThPOK expression gives rise to a preleukemic and self-perpetuating DN4 lymphoma precursor population. Our results collectively define a novel role for ThPOK as an oncogene and precisely map the stage in thymopoiesis susceptible to ThPOK-dependent tumor initiation.ThPOK | lymphoma | thymus | development | TCR

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Recognition of the product of a novel MHC TL region gene (27b) by a mouse γδ T cell receptor

Cited by 208 publications

References 46 publications

A second lineage of mammalian major histocompatibility complex class I genes.

A second lineage of mammalian major histocompatibility complex class I genes.

Developmental and tissue-specific expression of the Q5 k gene

Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas

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