Recognition of the tRNA structure: Everything everywhere but not all at once

Zhang, Jinwei

doi:10.1016/j.chembiol.2023.12.008

Cited by 10 publications

(1 citation statement)

References 176 publications

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“…The origin of tRNA-derived fragments (tRFs) can be traced back to tRNA. When tRNA is not sufficiently modified, tRNA stability could be disrupted and cleaved to tRFs or degraded by Dicer, endonuclease Z (RNase Z/ELAC2) and other RNA endonucleases (RNases) [ 15 – 17 ]. tRFs/tiRNAs are categorized into five types based on their cleavage sites on mature tRNA by different nucleases, including 5’-half, 3’-half, 5’-tRF, 3’-tRF, and i-tRF [ 18 – 20 ].…”

Section: Trna Biological Functionmentioning

confidence: 99%

Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies

Yuan,

Zhang,

Lyu

et al. 2024

Cell Death Discov.

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AbstracttRNA is the RNA type that undergoes the most modifications among known RNA, and in recent years, tRNA methylation has emerged as a crucial process in regulating gene translation. Dysregulation of tRNA abundance occurs in cancer cells, along with increased expression and activity of tRNA methyltransferases to raise the level of tRNA modification and stability. This leads to hijacking of translation and synthesis of multiple proteins associated with tumor proliferation, metastasis, invasion, autophagy, chemotherapy resistance, and metabolic reprogramming. In this review, we provide an overview of current research on tRNA methylation in cancer to clarify its involvement in human malignancies and establish a theoretical framework for future therapeutic interventions targeting tRNA methylation processes.

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