Recognitive nano-thin-film composite beads for the enantiomeric resolution of the metastatic breast cancer drug aminoglutethimide

Kadhirvel, Porkodi; Azenha, Manuel; Schillinger, Eric; Halhalli, Mahadeo R.; Silva, A. Fernando; Sellergren, Börje

doi:10.1016/j.chroma.2014.06.076

Cited by 11 publications

(5 citation statements)

References 20 publications

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“…Thus, of the previously reported custom-made functional monomers, including polymerisable adenine, purine and pyrimidine derivatives, 2,6-bis(acrylamido)pyridine (BAAPy) has been shown to be the most successful receptor and was used in the extraction of riboflavin from highly complex samples, such as beer and milk [16,17]. More recently, BAAPy was used in the development of molecularly imprinted polymers for the recognition of pyrimidine nucleosides [18], and in the preparation of composite beads for the enantiomeric resolution of the metastatic breast cancer drug aminoglutethimide by RAFT polymerisation [19]. Lastly, composite poloxamer nanomaterials containing R-thalidomide molecularly imprinted polymers based on BAAPy were recently used in enantioselective controlled release and targeted drug delivery [20].…”

Section: Introductionmentioning

confidence: 99%

Stoichiometric molecularly imprinted polymers for the recognition of anti-cancer pro-drug tegafur

Santos

Hall

Manesiotis

2016

Journal of Chromatography B

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2 Highlights Molecularly Imprinted Polymers for anti-cancer pro-drug tegafur were prepared. Stoichiometric imprinting and a custom-made functional monomer were utilised. High selectivity for tegafur vs. other analytes was demonstrated. Clean extracts and recoveries of up to 96% from aqueous samples were achieved. 3 AbstractMolecularly Imprinted Polymers (MIPs) targeting tegafur, an anti-cancer 5-fluorouracil pro-drug, have been prepared by stoichiometric imprinting using 2,6-bis(acrylamido)pyridine ( The synthesised imprinted polymer was employed in solid-phase extraction of the pro-drug using an optimised protocol that included a simple wash with the porogen used in the preparation of the material.Tegafur recoveries of up to 96% were achieved from aqueous samples and 92% from urine samples spiked with the template and three competing analytes. The results demonstrate the potential of the prepared polymers in the pre-concentration of tegafur from biological samples, which could be an invaluable tool in the monitoring of patient compliance and drug uptake and excretion.

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Section: Introductionmentioning

confidence: 99%

Stoichiometric molecularly imprinted polymers for the recognition of anti-cancer pro-drug tegafur

Santos

Hall

Manesiotis

2016

Journal of Chromatography B

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“…A key requirement to achieve promising imprinting inside the hydrogel polymer network is to have a strong interaction between the template and the functional monomer by self‐assembly (T–M). The stronger the interaction the better the imprinting efficiency . To detect this T–M orientation, molecular mechanics energy minimization was run using ACS/Chem 3D Ultra.…”

Section: Resultsmentioning

confidence: 99%

“…to create molecular memory (imprinting) inside the hydrogel network. Imprinting was aimed at creating tailor‐made cavities, shaped with a high specificity and affinity towards a target molecule . This has been achieved by introducing the ‘target/template’ during hydrogel formation.…”

Section: Introductionmentioning

confidence: 99%

Molecular imprinting in hydrogels using reversible addition-fragmentation chain transfer polymerization and continuous flow micro-reactor

Kadhirvel

Machado

Freitas

et al. 2015

J. Chem. Technol. Biotechnol.

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“…To solve this problem, the surface imprinting technique (SIT) emerged, which has been successfully used in the imprinted coating on a variety of nanomaterials [54]. Examples include the typical formats of silica particles [55,56,57,58], nanotubes [59], nanowires [60], and magnetic nanoparticles [61,62]. The SIT presents its significance for the formation of MIPs on the surface of support particles.…”

Section: High Performance Liquid Chromatography (Hplc)mentioning

confidence: 99%

Molecularly Imprinted Polymers for the Identification and Separation of Chiral Drugs and Biomolecules

et al. 2016

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Abstract:Molecularly imprinting polymers (MIPs) have been extensively applied in chromatography for the separation of chiral drugs. In this review, we mainly summarize recent developments of various MIPs used as chiral stationary phases (CSPs) in high performance liquid chromatography (HPLC), capillary electrochromatography (CEC), and supercritical fluid chromatography (SFC). Among them, HPLC has the advantages of straightforward operation and high selectivity. However, the low separation efficiency, due to slow interaction kinetics and heavy peak broadening, is the main challenge for the application of MIPs in HPLC. On the other hand, CEC possesses both the high selectivity of HPLC and the high efficiency of capillary electrophoresis. In CEC, electroosmotic flow is formed across the entire column and reduces the heavy peak broadening observed in HPLC mode. SFC can modify the low interaction kinetics in HPLC when supercritical fluids are utilized as mobile phases. If SFC and MIP-based CSPs can be well combined, better separation performance can be achieved. Particles, monoliths and membrane are typical formats of MIPs. Traditional MIP particles produced by bulk polymerization have been replaced by MIP particles by surface imprinting technology, which are highly consistent in size and shape. Monolithic MIPs are prepared by in situ method in a column, greatly shortening the pre-preparation time. Some novel materials, such as magnetic nanoparticles, are integrated into the MIPs to enhance the controllability and efficiency of the polymerization. This review will be helpful to guide the preparation, development, and application of MIPs in chromatographic and electrophoretic enantioseparation.

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Recognitive nano-thin-film composite beads for the enantiomeric resolution of the metastatic breast cancer drug aminoglutethimide

Cited by 11 publications

References 20 publications

Stoichiometric molecularly imprinted polymers for the recognition of anti-cancer pro-drug tegafur

Stoichiometric molecularly imprinted polymers for the recognition of anti-cancer pro-drug tegafur

Molecular imprinting in hydrogels using reversible addition-fragmentation chain transfer polymerization and continuous flow micro-reactor

Molecularly Imprinted Polymers for the Identification and Separation of Chiral Drugs and Biomolecules

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