Recognizing off target drug effects in the gut and brain

Abstract

It is difficult to recognize off-target drug effects, leading to delays in diagnosis and predisposing patients to additional harms. Key components in the formulation of the correct diagnosis include the temporal sequence of events. The sentinel injury may target the gut and brain because of common intermediary metabolites and neuroactive substrates. The description of the complaint may vary among practitioners. The biggest issue in recognizing off target drug effects is to consider the possibility.

Repetitive Skin Focused Disorders May Express a Functional Connectome

“…[53][54] A review of classic drug-induced neurotoxic syndromes reveal specific vulnerabilities in the basal ganglia, the autonomic nervous system, and areas related to sleep, anxiety and thought. [55][56][57][58][59][60] The enzymatic oxidation of cholesterol to bile provides key metabolic functions, such as drug metabolism, the absorption of dietary lipids and protection of the endocrine system. Drug metabolism uses the same pathway as cholesterol catabolism.…”