Recognizing severe fatigue and decline in quality of life in Hodgkin lymphoma survivors

Trachtenberg, E.A.; Gurion, Ronit; Mashiach, Tatiana; Tadmor, Tamar; Kedmi, Meirav; Dann, Eldad J.

doi:10.1080/10428194.2019.1641803

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…Moreover, young Hodgkin's Lymphoma survivors' evidence high levels of persistent physical fatigue, emotional distress, and cognitive decline, with a progressive reduction in the quality of life (Mounier et al, 2019;Trachtenberg et al, 2019). Despite the well-known relationship between aerobic capacity and lung function, the improvements in lung function are correlated with highest physical fitness levels during childhood and adolescence through early adulthood, and being active during evolutive age is associated with improved lung function in adulthood (Puente-Maestu & Stringer, 2018).…”

Section: Discussionmentioning

confidence: 99%

Assessing the Effects of Physical Activity on Children and Adolescents Hodgkin’s Lymphoma Survivors: A Systematic Review

Colella

Monacis

2021

EJPE

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Physical activity can improve metabolism, lung functionality, aerobic capacity, physical fitness components and quality of life among children and adults diagnosed with cancer. The daily practice of physical activity and physical fitness levels are important factors to cancer care and prevention, showing positive effects on the immune system and hematologic malignancies. Hodgkin's lymphoma is a cancer of the lymphatic system, originated from B lymphocytes (a type of white blood cell) present in the lymph nodes, spleen, bone marrow, blood and numerous other organs. This system has a defense function, protecting organism from external agents and diseases. The aim of this systematic review is to analyze the effects of physical activity on fatigue, physical fitness levels and quality of life in children and adolescents Hodgkin's lymphoma survivors. The PRISMA protocol was used to conduct a systematic review of SportDiscuss, PubMed, Scopus, Web of Science and Pedro databases. 4 articles met inclusion criteria (randomized controlled trials, pre-post intervention studies with and without control group, pilot studies or preliminary studies; full-text and peer-reviewed studies; diagnosis of lymphoma during childhood or adolescence; studies using validated assessment tools or a combination of validated and non-validated tools; studies including physical activity, physical fitness and quality of life as outcomes; studies focusing Hodgkin Lymphoma exclusively; studies published in English). Results evidence a progressive decline in physical activity levels, a progressive decrease in VO2max, increased fatigue, muscular strength reduction, and major risk of cardiovascular diseases in Hodgkin’s Lymphoma survivors. Future research should clarify the effects of physical activity on HL management and etiology, to reach definitive conclusions and develop specific policy recommendations. Article visualizations:<img src="/-counters-/edu_01/0783/a.php" alt="Hit counter" />

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Section: Discussionmentioning

confidence: 99%

Assessing the Effects of Physical Activity on Children and Adolescents Hodgkin’s Lymphoma Survivors: A Systematic Review

Colella

Monacis

2021

EJPE

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“…HL survivors suffer from decreased functioning, mainly fatigue, as demonstrated by the GHSG in their early trials when compared to controls [68]. A recent survey involving 120 HL survivors showed severe levels of general fatigue (28%), physical fatigue (26%), and reduced activity (22%) when measured using the Multidimensional Fatigue Inventory [69], In contrast, 21 patients reported no fatigue-related symptoms. Concerning associations with treatment type, patients who received ABVD and radiotherapy reported the highest levels of fatigue compared to patients treated with BEACOPP.…”

Section: Fatigue and Quality Of Lifementioning

confidence: 99%

How I Follow Hodgkin Lymphoma in First Complete (Metabolic) Remission?

Milunović

2024

Medicina

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Hodgkin lymphoma is characterized by a high cure rate in the modern era of medicine regardless of stage, but patients suffer from a high risk of comorbidity associated with the administered therapy. The main aim of this review article is to assess and analyze the various comorbidities associated with Hodgkin lymphoma and address the survivorship of patients, including fertility, secondary cancers due to cardiovascular toxicity, and quality of life. Furthermore, this review explores the optimal strategy for detecting relapse. The treatment paradigm of Hodgkin lymphoma has shifted, with a paradigm shift toward achieving a high cure rate and low toxicity as a standard of care in this patient population. Checkpoint inhibitors, especially nivolumab, in combination with chemotherapy are increasingly being studied in the first line of therapy. However, their long-term toxicity remains to be assessed in longer follow-up. In conclusion, Hodgkin lymphoma survivors, regardless of their treatment, should be followed up individually by a multidisciplinary survivorship team in order to detect and properly treat the long-term side effects of therapy.

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“…After intensive treatment, QoL can be impaired due to treatment-induced organ dysfunction, psychological problems, fatigue, persisting gonadal and cognitive impairment and social discomfort/difficulties. It has also been demonstrated that QoL was decreased in the long-term (adjusted for age, sex and education status) after curative treatment, significantly and persistently affecting the well-being of survivors ( 19 – 22 ). Economic difficulty and fatigue emerged as being most closely correlated with all affected domains of QoL ( 23 ).…”

Section: Introductionmentioning

confidence: 99%

Patient-reported outcomes in Hodgkin lymphoma trials: a systematic review

Oliva,

Ionova,

Laane

et al. 2024

Front. Oncol.

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BackgroundLymphoma treatment can lead to long-term consequences such as fatigue, infertility and organ damage. In clinical trials, survival outcomes, clinical response and toxicity are extensively reported while the assessment of treatment on quality of life (QoL) and symptoms is often lacking.ObjectiveWe evaluated the use and frequency of patient-reported outcome (PRO) instruments used in randomized controlled trials (RCTs) for Hodgkin lymphoma (HL) and their consistency of reporting.MethodsMEDLINE, CENTRAL and trial registries for RCTs investigating HL were systematically searched from 01/01/2016 to 31/05/2022. Following trial selection, trial, patient characteristics and outcome data on the use of PRO measures (PROMs) and reporting of PROs using a pre-defined extraction form were extracted. To assess reporting consistency, trial registries, protocols and publications were compared.ResultsWe identified 4,222 records. Following screening, a total of 317 reports were eligible for full-text evaluation. One hundred sixty-six reports of 51 ongoing/completed trials were included, of which 41% of trials were completed and 49% were ongoing based on registry entries. Full-text or abstract were available for 33 trials. Seventy percent of trials were conducted in the newly diagnosed disease setting, the majority with advanced HL. In 32 trials with published follow-up data, the median follow-up was 5.2 years. Eighteen (35%) completed/ongoing trials had mentioned PRO assessment in registry entries, protocol or publications. Twelve trials (67%) had published results and only 6 trials (50%) reported on PROs in part with the exception of 1 trial where PROs were evaluated as secondary/exploratory outcome. The most referenced global PROM was the EORTC-QLQ-C30 (12 studies), the EQ-5D (3 studies) and the FACT-Neurotoxicity (3 studies). FACT-Lymphoma, a disease-specific PROM for non-HL was mentioned in one ongoing trial. None of the trials referenced the EORTC QLQ-HL27, another disease-specific PROM developed specifically for HL patient’s QoL assessment.DiscussionsOnly one-third of RCTs in HL report PROs as an outcome and only half present the outcome in subsequent publications, showcasing the underreporting of PROs in trials. Disease-specific PROMs are underutilized in the assessment of QoL in HL patients. Guidance on the assessment of PROs is needed to inform on comprehensive outcomes important to patients.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=391552, identifier CRD42023391552.

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Recognizing severe fatigue and decline in quality of life in Hodgkin lymphoma survivors

Cited by 6 publications

References 25 publications

Assessing the Effects of Physical Activity on Children and Adolescents Hodgkin’s Lymphoma Survivors: A Systematic Review

Assessing the Effects of Physical Activity on Children and Adolescents Hodgkin’s Lymphoma Survivors: A Systematic Review

How I Follow Hodgkin Lymphoma in First Complete (Metabolic) Remission?

Patient-reported outcomes in Hodgkin lymphoma trials: a systematic review

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