Recollection and prior knowledge recruit the left angular gyrus during recognition

Bellana, Buddhika; Ladyka‐Wojcik, Natalia; Lahan, Shany; Moscovitch, Morris; Grady, Cheryl L.

doi:10.1007/s00429-022-02597-5

Cited by 8 publications

(3 citation statements)

References 125 publications

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“…LV2 PLS results also indicated that older Post-Meno females exhibited lower levels of bilateral occipitotemporal, parahippocampal and inferior parietal cortex activity at encoding and retrieval, which was correlated with lower spatial context memory and higher recognition memory. Taken together, LV 1 and LV 2 results suggest that spatial context memory reductions in Post-Meno females compared to Pre-Meno females may in part be due to menopause/endocrine aging affecting the ability to reactivate lateral PFC, midline cortical and angular gyrus at retrieval (LV1) (Bellana et al, 2023;Morcom, 2014;Vilberg & Rugg, 2014;Wing et al, 2015); and, chronological age-related reductions in occipitotemporal, parahippocampal and inferior parietal activity at encoding and retrieval. These results highlight the combined influences of menopause and chronological aging on episodic memory and related brain function in middle-aged Post-Meno females.…”

Section: Discussionmentioning

confidence: 90%

“…Prior episodic memory studies have found that greater activity in these regions is associated with successful episodic encoding and contextual recollection (de Chastelaine et al, 2016; Kim, 2010; Rugg & Vilberg, 2013). Similarly, increased activity in lateral PFC activity has been consistently observed during spatial context memory tasks at encoding and retrieval (Mitchell & Johnson, 2009; Rajah et al, 2008; Rajah et al, 2010), and increased left angular gyrus activity has been observed during associative object-context encoding and recollection (Bellana et al, 2023; Branzi et al, 2021; Maillet & Rajah, 2014b). In addition, Jacobs et al (2016) reported no significant group differences in lateral PFC activity during a verbal episodic encoding tasks between Pre-Meno and Post-Meno females, consistent with our current findings.…”

Section: Discussionmentioning

confidence: 90%

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Menopause status and within group differences in chronological age affect the functional neural correlates of spatial context memory in middle-aged females

Crestol,

Rajagopal,

Lissaman

et al. 2023

Preprint

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Reductions in the ability to encode and retrieve past experiences in rich spatial contextual detail (episodic memory) are apparent by midlife – a time when most females experience spontaneous (natural) menopause. Yet, little is known about how menopause status and chronological aging influence the functional brain networks associated with episodic memory. Female-specific investigations of memory-related brain function at midlife are thus warranted to advance our knowledge of how menopause and chronological aging affect cognitive brain aging in middle-aged females. We conducted an event-related task fMRI study of episodic memory for spatial context and used multivariate partial least squares (PLS) to investigate how chronological age and retrieval accuracy correlated with brain activity in 31 middle-aged premenopausal (age range: 39.55 – 53.30 yrs,Mage= 44.41 yrs,SDage= 3.12 yrs) and 41 middle-aged postmenopausal females (age range: 46.70 to 65.14 yrs,Mage= 57.05 yrs,SDage= 3.93 yrs). Behaviorally, both advanced age and postmenopausal status contributed to lower spatial context memory. PLS analysis of the fMRI data indicated that premenopausal, but not postmenopausal, females exhibited a positive correlation between lateral PFC, midline cortical, and angular gyrus activity during retrieval and spatial context memory performance. Also, only postmenopausal females advanced age was correlated with decreased activity in occipitotemporal, parahippocampal, and inferior parietal during encoding and retrieval and poorer spatial context memory performance. Our results highlight that both menopause and chronological aging affect episodic memory and related brain function in middle-aged females.Significance StatementThis study advances our understanding of how menopause status and chronological age affect memory-related brain function in middle-aged females. Using data driven multivariate partial least squares (PLS) regression for behavioral analysis and PLS correlation for fMRI analysis we found: 1) advanced age and post-menopause status negatively affected spatial context memory, 2) Only premenopausal females exhibited overlap in encoding and retrieval activity in angular gyrus, midline cortical regions, and prefrontal cortex, which correlated with better spatial context retrieval accuracy, and 3) age was correlated with reduced encoding and retrieval activity in occipitotemporal, parahippocampal, inferior parietal in only post-menopause, and this was associated with poorer spatial context memory.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 90%

Menopause status and within group differences in chronological age affect the functional neural correlates of spatial context memory in middle-aged females

Crestol,

Rajagopal,

Lissaman

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Instead, the ventral PPC displayed heightened neural activity, similar to what we observed in the dorsal PPC. One explanation may lie in the functional heterogeneity of the ventral PPC, particularly the angular gyrus, which has distinct cytoarchitectonic subregions -PGa and PGp -with divergent functional roles (Bellana, Ladyka-Wojcik, Lahan, Moscovitch, & Grady, 2023;Niu & Palomero-Gallagher, 2023;Rockland & Graves, 2023;Uddin et al, 2010;Wu et al, 2009). The former appears aligned with the dorsal PPC and the frontoparietal network, while the latter is more closely associated with the DMN (Seghier, 2013(Seghier, , 2023Seghier, Fagan, & Price, 2010).…”

Section: Discussionmentioning

confidence: 99%

Hippocampal-parietal cortex causal directed connectivity during human episodic memory formation: Replication across three experiments

Das,

Menon

2023

Preprint

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While extensive research has focused on hippocampus-prefrontal circuits in episodic memory and spatial navigation, the role of hippocampus-parietal cortex circuits remains understudied. We employed intracranial EEG to investigate these circuits across three different memory experiments, revealing a consistent, asymmetric pattern of higher causal information flow from the hippocampus to both lateral and medial posterior parietal cortex (PPC). This directional information flow was observed during both memory encoding and recall and across verbal and spatial episodic memory domains. Importantly, this directed information flow was not contingent upon activation or suppression states in the hippocampus or PPC. Frequency-specific directional interactions were also identified, with greater hippocampal-to-PPC flow in the delta-theta band and the reverse in the beta band. The robustness of these results was demonstrated through Bayesian replication analysis. Our findings shed new light on the frequency-dependent signaling within hippocampus-parietal circuits, broadening our understanding of their critical roles in human episodic memory.

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Architecture and connectivity of the human angular gyrus and of its homolog region in the macaque brain

Niu

Palomero‐Gallagher

2022

Brain Struct Funct

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The angular gyrus roughly corresponds to Brodmann’s area 39, which is a multimodal association brain region located in the posterior apex of the human inferior parietal lobe, at its interface with the temporal and occipital lobes. It encompasses two cyto- and receptor architectonically distinct areas: caudal PGp and rostral PGa. The macaque brain does not present an angular gyrus in the strict sense, and the establishment of homologies was further hindered by the fact that Brodmann defined a single cytoarchitectonic area covering the entire guenon inferior parietal lobule in the monkey brain, i.e. area 7. Latter architectonic studies revealed the existence of 6 architectonically distinct areas within macaque area 7, further connectivity and functional imaging studies supported the hypothesis that the most posterior of these macaque areas, namely Opt and PG, may constitute the homologs of human areas PGp and PGa, respectively. The present review provides an overview of the cyto-, myelo and receptor architecture of human areas PGp and PGa, as well as of their counterparts in the macaque brain, and summarizes current knowledge on the connectivity of these brain areas. Finally, the present study elaborates on the rationale behind the definition of these homologies and their importance in translational studies.

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Recollection and prior knowledge recruit the left angular gyrus during recognition

Cited by 8 publications

References 125 publications

Menopause status and within group differences in chronological age affect the functional neural correlates of spatial context memory in middle-aged females

Menopause status and within group differences in chronological age affect the functional neural correlates of spatial context memory in middle-aged females

Hippocampal-parietal cortex causal directed connectivity during human episodic memory formation: Replication across three experiments

Architecture and connectivity of the human angular gyrus and of its homolog region in the macaque brain

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