Recolonization of group B Streptococcus (GBS) in women with prior GBS genital colonization in pregnancy

Abstract

These results suggest that patients with a history of GBS are at a significantly higher risk of GBS recolonization in subsequent pregnancies.

Recurrence of group B streptococcus colonization in successive pregnancies

“…Among American women, rates of recurrent GBS colonization are reported between 40% and 53%, while among women who tested GBS negative in a prior pregnancy, GBS colonization is 15% to 19%. [10][11][12] Together with the present study, these results suggest that a 40% to 50% recurrent colonization risk is a reasonable estimate and also support the generalizability of our observations, in which cases were ascertained using unselected culture results from a single center. None of these reports, including the present study, allow differentiation between persistent colonization and new colonization, a distinction that would require molecular analysis not routinely performed in clinical labs.…”

“…Between 13% and 54% of women with an initial positive culture will no longer be colonized at the time of delivery. [5][6][7][8] Recurrent GBS colonization between pregnancies is reported at rates of 38% to 53%, [9][10][11][12] but a clear understanding of the factors influencing GBS colonization over time is lacking. We posited that if microbiological and clinical risk factors for colonization could be identified from an index pregnancy, an opportunity may exist to use this information in the management of a subsequent pregnancy.…”

The prevalence and risk factors of group B streptococcus colonization in Iranian pregnant women

“…However, the variety in statistics can also be a result of other confining factors such as site and technique of culturing, as well as gestational age. Even though previous history of GBS colonization is a great risk factor (15), it should be noted that the status of colonization might be transient, intermittent or even chronic (16), thus mothers should be evaluated in each pregnancy. Despite the fact that preterm labor and ROM were introduced as remarkable complications of GBS colonization (3), no significant statistical difference was detected in carrier and non-carrier populations of our study.…”

Prevention of Early‐onset Neonatal Group B Streptococcal Disease

“…[17][18][19][20][21] The risk of EOGBS disease in the baby in this circumstance is likely to be around 1 in 700 to 1 in 800. 3 If bacteriological tests for GBS are to be performed in pregnancy they should ideally be performed at 35-37 weeks of gestation 22 in order to determine carriage status close to delivery.…”