“…Spidroin is very large protein (>300 kDa), typically classified into spidroin‐I and spidroin‐II due to differences in proline and tyrosine amino acids content; these two are responsible for silk strength and elasticity, respectively (Butler, ). Recombinant spidroin was reported to promote cell proliferation and angiogenesis in wounds (Moisenovich et al, ; Moisenovich et al, ; Veith, Henderson, Spencer, Sligar, & Baker, ). Additionally, spidroin has a potential medical application due to a fascinating combination of wide temperature‐ and pH‐stability, biodegradability, biocompatibility, nontoxicity, and nonimmunogenicity (Brown, Whaite, MacLeod, Macdonald, & Rosei, ; Butler, ).…”