Recombinant Capripoxvirus Expressing the Hemagglutinin Protein Gene of Rinderpest Virus: Protection of Cattle against Rinderpest and Lumpy Skin Disease Viruses

Development of a Dual Recombinant Vaccine To Protect Small Ruminants against Peste-des-Petits-Ruminants Virus and Capripoxvirus Infections

“…Capripoxvirus is therefore an ideal poxvirus vector for the development of recombinant multivalent vaccines to enable delivery of immunogenic genes from other ruminant pathogens that share the same geographical distribution. With that in mind, the attenuated capripoxvirus strain KS-1 was used to develop an effective recombinant rinderpest vaccine expressing the fusion (F) and hemagglutinin (H) proteins of the rinderpest virus (22,23). This vaccine has now been tested and shown to be effective in long-term trials (19,20).…”

Recombinant Viral Vector Vaccines for the Veterinary Use.

“…Therefore it would make a more suitable viral vector for expressing immunogenic antigens of veterinary importance in their species. Romero et al [94][95][96][97] reported the constructions of recombinant CPV, containing the fusion (F) or haemagglutinin (H) gene of rinderpest virus, and their vaccine efficacy in goats or cattle against rinderpest, peste des petits, or lumpy skin diseases. Wade-Evans et al [121] constructed a recombinant CPV expressing the major core protein VP7 of bluetongue virus (BTV).…”

The Jenner bicentenary; still uses for smallpox vaccine

“…To this end raccoonpox recombinant rabies and capripoxvirus recombinant rinderpest vaccines are being developed [18,19]; the latter has the advantage that the recombinant vaccine also immunizes against lumpy skin disease the natural disease caused by the vector [19].…”