Recombinant FSH versus clomiphene citrate for ovarian stimulation in couples with unexplained infertility and male subfertility undergoing intrauterine insemination: a randomized trial

Berker, Bülent; Kahraman, Korhan; Taşkın, Salih; Şükür, Yavuz Emre; Sönmezer, Murat; Atabekoğlu, Cem Somer

doi:10.1007/s00404-011-1997-4

Cited by 47 publications

(56 citation statements)

References 14 publications

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“…It has been shown in many studies in the literature that the use of FSH and hMG is superior to CC use (24)(25)(26)(27). Although we observed that gestational rates were low in the CC group, we could not show the difference due to the small sample size.…”

Section: Discussioncontrasting

confidence: 87%

Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

Atasever¹,

Kalem²,

Hatırnaz³

et al. 2016

J Turkish German Gynecol Assoc

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Objective:The aim of the present retrospective study was to evaluate intrauterine insemination (IUI) clinical experiences and to define the variables for predicting success. Material and Methods:The present study was an observational trial performed in a private IVF center on subfertile couples who had applied for treatment between 2002 and 2012, in which the data of 503 IUI cases were retrospectively reviewed. Couples who had been diagnosed with unexplained and mild male subfertility were included. The primary outcome measure was the clinical pregnancy rate in an attempt to form a predictive model for the odds of a clinical pregnancy. Recorded parameters were used to determine the prediction model. Results:Utilizing univariate logistic regression analysis, clinical pregnancy was positively associated with the duration of infertility (OR=1.09, p=0.089), secondary infertility (OR=1.77, p=0.050), and +4 sperm motility after preparation (OR=1.03, p=0.091). Following an adjustment analysis involving a multivariate logistic regression, clinical pregnancy was still found to positively associate with secondary infertility (OR=2.51, p=0.008). Conclusion:IUI success in secondary infertile couples who were in the unexplained infertility and mild male subfertility groups was higher than that in primary infertile couples, and the chances of pregnancy increased as sperm numbers with +4 motility increased. It is difficult to concomitantly evaluate all these parameters and to determine a predictive parameter in IUI independent from other factors. (J Turk Ger Gynecol Assoc 2016; 17: 134-8) Keywords: Intrauterine insemination, unexplained infertility, male subfertility Received: 1 April, 2016 Accepted: 25 July, 2016 Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

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Section: Discussioncontrasting

confidence: 87%

Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

Atasever¹,

Kalem²,

Hatırnaz³

et al. 2016

J Turkish German Gynecol Assoc

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“…First, an increasingly compelling case (Table 2) can be made in support of low-dose (%75 IU) GT regimens, for which per-cycle pregnancy rates of 8.7%-16.3% and absent highorder gestation have been noted in prospective randomized trials (28,(59)(60)(61)(62)(63)(64). A more mixed record was noted for the twin gestation category.…”

Section: Ovarian Stimulation With Iui: Is the Plurality Of Births Mitmentioning

confidence: 95%

Ovarian stimulation and intrauterine insemination at the quarter centennial: implications for the multiple births epidemic

McClamrock

Jones

Adashi

2012

Fertility and Sterility

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“…It is important to reflect on the differences between these regimes. [24,25]. Clomiphene an anti-oestrogen is a selective oestrogen receptor modulator (SERM), a nonsteroidal oestrogen that binds to the oestrogen receptors at multiple sites throughout the reproductive tract and can act as an oestrogen agonist or as an antagonist.…”

Section: Discussionmentioning

confidence: 99%

Factors Leading to Pregnancies in Stimulated Intrauterine Insemination Cycles and the Use of Consecutive Ejaculations Within a Small Clinic Environment

Bahadur

Almossawi

IIlahibuccus

et al. 2016

J Obstet Gynecol India

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Introduction Understanding and improving IUI pregnancy rates has enormous global appeal and application. This pilot study goes one step further by utilising consecutive ejaculates from men with oligozoospermia and comparing with normozoospermic male group. Materials and Methods A retrospective analysis was performed on 117 IUI-stimulated treatment cycles in a small fertility clinic in North Middlesex University Hospitals Trust, UK, within a NHS setting. Risks of OHSS and multiple births are carefully controlled. Results In our cohort, several factors are associated with positive IUI pregnancies and these were: age of the woman, inseminating with C5 total progressive motile sperm; having C50 % Grade A sperm progression and having C1 Dr. Gulam Bahadur is a past member of the HFEA. His main involvement is in andrology with special emphasis on diagnostic analyses, male cancer patients, counselling, sperm donor recruitment and sperm freezing, and recovery rates following cryopreservation. Important ways to optimise pregnancy rates in simple first-line treatment intrauterine insemination are being researched and applied within a number of UK NHS Trust Hospitals. Dr Bahadur has made significant contributions to the understanding of semen qualities in subfertile males, cancer patients, adolescent cancer patients and produced one of the first reports on ovarian tissue freezing for cancer patients.The Journal of Obstetrics and Gynecology of India (September-October 2016) 66(S1):S513-S520 DOI 10.1007/s13224-016-0876-0 123follicle achieved with a realistic hMG dosage, hCG trigger and IUI of 29.7 h (2.5-38.4 h), with an endometrial thickness of 10.7 mm (6.6-13.4 mm). Bifollicular presence in at least half the cases along with hMG protocols added usefully to the pregnancy outcomes. Conclusions The pregnancy rates per cycle were 19 and 23 % in the consecutive ejaculates and non-consecutive ejaculate groups, respectively, P = 0.59. For the whole cohort, the pregnancy rate was 20.51 % per cycle and 33.8 % per women. This approach if validated with large RCT will have universally beneficial effects.

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Recombinant FSH versus clomiphene citrate for ovarian stimulation in couples with unexplained infertility and male subfertility undergoing intrauterine insemination: a randomized trial

Cited by 47 publications

References 14 publications

Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

Ovarian stimulation and intrauterine insemination at the quarter centennial: implications for the multiple births epidemic

Factors Leading to Pregnancies in Stimulated Intrauterine Insemination Cycles and the Use of Consecutive Ejaculations Within a Small Clinic Environment

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