Recombinant growth hormone therapy for cystic fibrosis in children and young adults

Thaker, Vidhu; Haagensen, Alexandra; Jagannath, Vanitha A; Fedorowicz, Zbys; Houston, Brian W

doi:10.1002/14651858.cd008901

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…Administration of recombinant growth hormone significantly increases height, growth velocity, and serum levels of IGF-1 and IGFBP-3, but not lung functions [ 285 ]. Meta-analyses show that growth hormone therapy improves the intermediate outcomes in height, weight, and lean tissue mass, but pulmonary function improvement is inconsistent [ 286 ]. No significant changes in quality of life, clinical status, or side-effects are observed [ 287 ].…”

Section: Igf-1 Signaling In Cystic Fibrosis (Cf)mentioning

confidence: 99%

Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases

Wang

Guo

et al. 2018

BioMed Research International

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Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies. The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer. Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases.

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Section: Igf-1 Signaling In Cystic Fibrosis (Cf)mentioning

confidence: 99%

Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases

Wang

Guo

et al. 2018

BioMed Research International

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“…If a systematic review of the studies reveals a benefit in pulmonary function, the quality of life, and morbidity (including hospitalisations) for people with CF, this will serve as an important adjunct to their current therapy. This is an update of a previously published review (Thaker 2013).…”

Section: Why It Is Important To Do This Reviewmentioning

confidence: 91%

Recombinant growth hormone therapy for cystic fibrosis in children and young adults

Thaker¹,

Haagensen

Carter

et al. 2013

Cochrane Database of Systematic Reviews

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The impact of hormones on lung development and function: an overlooked aspect to consider from early childhood

Pelizzo,

Calcaterra,

Baldassarre

et al. 2024

Front. Endocrinol.

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The impact of hormones on the respiratory system constitutes a multifaceted and intricate facet of human biology. We propose a comprehensive review of recent advancements in understanding the interactions between hormones and pulmonary development and function, focusing on pediatric populations. We explore how hormones can influence ventilation, perfusion, and pulmonary function, from regulating airway muscle tone to modulating the inflammatory response. Hormones play an important role in the growth and development of lung tissues, influencing them from early stages through infancy, childhood, adolescence, and into adulthood. Glucocorticoids, thyroid hormones, insulin, ghrelin, leptin, glucagon-like peptide 1 (GLP-1), retinoids, cholecalciferol sex steroids, hormones derived from adipose tissue, factors like insulin, granulocyte-macrophage colony-stimulating factor (GM-CSF) and glucagon are key players in modulating respiratory mechanics and inflammation. While ample evidence underscores the impact of hormones on lung development and function, along with sex-related differences in the prevalence of respiratory disorders, further research is needed to clarify their specific roles in these conditions. Further research into the mechanisms underlying hormonal effects is essential for the development of customizing therapeutic approaches for respiratory diseases. Understanding the impact of hormones on lung function could be valuable for developing personalized monitoring approaches in both medical and surgical pediatric settings, in order to improve outcomes and the quality of care for pediatric patients.

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Recombinant growth hormone therapy for cystic fibrosis in children and young adults

Abstract: Background-Cystic fibrosis is an inherited condition causing disease most noticeably in the lungs, digestive tract and pancreas. People with cystic fibrosis often have malnutrition and growth

Cited by 3 publications

References 38 publications

Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases

Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases

Recombinant growth hormone therapy for cystic fibrosis in children and young adults

The impact of hormones on lung development and function: an overlooked aspect to consider from early childhood

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