Recombinant human erythropoietin as adjuvant treatment for autologous blood donation in elective surgery with large blood needs (> or=5 units): a randomized study

Abstract

In nonanemic patients donating 5 units of blood, rHuEPO associated with intravenous iron increased total red cell production. However, no difference was found between the rHuEPO and placebo groups with regard to the number of units of autologous blood donated of the number of patients receiving allogeneic blood transfusion.

The variability of compensatory erythropoiesis in repeated autologous blood donation

“…Consequently, net RBC production could be optimized by the continued donation of additional units right up until the time of surgery. Such a strategy should be reserved for patients who will undergo elective surgery with a high risk of significant operative bleeding 25 …”

Vigilance of alternatives to blood components

“…EPO has been used preoperatively to increase the hemoglobin in patients with anemia and in those patients who are undergoing PAD. During the process of PAD, EPO is used in combination with oral or intravenous iron to increase the hemoglobin 11–13 . The aim is that following pre‐donation, the patients increase their hemoglobin levels again preoperatively in an attempt to enter surgery with a hematocrit and hemoglobin level similar to that if they had not undergone PAD.…”

Practice Guidelines for Perioperative Blood Management

“…[48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] The literature is insufficient to evaluate the efficacy of erythropoietin with iron compared with erythropoietin without iron. [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] The literature is insufficient to evaluate the efficacy of erythropoietin with iron compared with erythropoietin without iron.…”