Recombinant human erythropoietin improves functional recovery in patients with severe traumatic brain injury: A randomized, double blind and controlled clinical trial

Li, Zhongmin; Xiao, Yi; Zhu, Jun; Geng, Fei; Guo, Chuan-jun; Chong, Zonglei; Wang, Le Xin

doi:10.1016/j.clineuro.2016.09.001

Cited by 46 publications

(41 citation statements)

References 18 publications

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“…In general, ELISA samples showed less volatility over time (42, 49, 68, 81, 91). Specifically, they tended to have elevated levels over a prolonged period of time as compared to the automated, clinical assays (42, 49, 52, 77, 81, 85, 86, 91). …”

Section: Resultsmentioning

confidence: 95%

“…Secondary increases (“peaks”) of S100B were found in several studies and correlated with secondary adverse events (7, 41, 51, 58, 75, 90). Some clinical trials noted a faster decrease of S100B in serum over time in the trial group as compared to placebo (34, 42, 81, 82). …”

Section: Resultsmentioning

confidence: 99%

“…Commercial or custom made enzyme-linked immunosorbent assays (ELISAs) were used in some studies (21, 34, 35, 40, 42, 44, 49, 52, 57, 61, 67, 68, 77, 81, 85, 86, 91), as well as other techniques (or not mentioned in the text) (36, 51, 55, 66, 69, 71), even if a majority used clinically available assays such as the (C)LIA-mat system from Sangtec/DiaSorin (7, 11, 18, 37–39, 41, 43, 45–48, 50, 53, 54, 56, 58–60, 62–65, 70, 72–76, 78–80, 82–84, 87–90, 92–95). In general, ELISA samples showed less volatility over time (42, 49, 68, 81, 91). Specifically, they tended to have elevated levels over a prolonged period of time as compared to the automated, clinical assays (42, 49, 52, 77, 81, 85, 86, 91).…”

Section: Resultsmentioning

confidence: 99%

“…While some studies had more than 24 h between sampling times (42, 52, 57, 58, 81, 87, 94, 95), generally the studies had a sampling frequency of every 24 h (7, 18, 21, 35–38, 41, 43, 44, 48–51, 53, 54, 56, 60, 61, 70, 72, 74–86, 88–90, 93), or sometimes twice daily (11, 34, 45–47, 67, 68, 73), or every 4–6 h (39, 40, 55, 62–64, 66, 69, 71, 91, 92). In contrast to the other biomarkers, there were some studies that assessed S100B hourly in order to track the serum dynamics (59, 65).…”

Section: Resultsmentioning

confidence: 99%

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Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain Injury Dynamics: A Systematic Review

et al. 2017

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BackgroundThe proteins S100B, neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and neurofilament light (NF-L) have been serially sampled in serum of patients suffering from traumatic brain injury (TBI) in order to assess injury severity and tissue fate. We review the current literature of serum level dynamics of these proteins following TBI and used the term “effective half-life” (t1/2) in order to describe the “fall” rate in serum.Materials and methodsThrough searches on EMBASE, Medline, and Scopus, we looked for articles where these proteins had been serially sampled in serum in human TBI. We excluded animal studies, studies with only one presented sample and studies without neuroradiological examinations.ResultsFollowing screening (10,389 papers), n = 122 papers were included. The proteins S100B (n = 66) and NSE (n = 27) were the two most frequent biomarkers that were serially sampled. For S100B in severe TBI, a majority of studies indicate a t1/2 of about 24 h, even if very early sampling in these patients reveals rapid decreases (1–2 h) though possibly of non-cerebral origin. In contrast, the t1/2 for NSE is comparably longer, ranging from 48 to 72 h in severe TBI cases. The protein GFAP (n = 18) appears to have t1/2 of about 24–48 h in severe TBI. The protein UCH-L1 (n = 9) presents a t1/2 around 7 h in mild TBI and about 10 h in severe. Frequent sampling of these proteins revealed different trajectories with persisting high serum levels, or secondary peaks, in patients with unfavorable outcome or in patients developing secondary detrimental events. Finally, NF-L (n = 2) only increased in the few studies available, suggesting a serum availability of >10 days. To date, automated assays are available for S100B and NSE making them faster and more practical to use.ConclusionSerial sampling of brain-specific proteins in serum reveals different temporal trajectories that should be acknowledged. Proteins with shorter serum availability, like S100B, may be superior to proteins such as NF-L in detection of secondary harmful events when monitoring patients with TBI.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain Injury Dynamics: A Systematic Review

et al. 2017

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“…One of the reasons these trials have failed is believed to be a lack of methods to validate the therapeutic effect and instead focus predominantly on late outcomes, which may be influenced by a multitude of factors, thus introducing noise and possibly drowning possible treatment effects. In a recent, smaller study of erythropoietin in human TBI, S100B was used as a proxy of treatment effect with decreasing levels seen in patients treated with the drug vs. placebo, thus suggesting a lesser extent of tissue injury [94]. …”

Section: S100b As a Surrogate Marker For Treatment Efficacymentioning

confidence: 99%

A review of the clinical utility of serum S100B protein levels in the assessment of traumatic brain injury

2016

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BackgroundIn order to improve injury assessment of brain injuries, protein markers of pathophysiological processes and tissue fate have been introduced in the clinic. The most studied protein “biomarker” of cerebral damage in traumatic brain injury (TBI) is the protein S100B. The aim of this narrative review is to thoroughly analyze the properties and capabilities of this biomarker with focus on clinical utility in the assessment of patients suffering from TBI.ResultsS100B has successfully been implemented in the clinic regionally (1) to screen mild TBI patients evaluating the need to perform a head computerized tomography, (2) to predict outcome in moderate-to-severe TBI patients, (3) to detect secondary injury development in brain-injured patients and (4) to evaluate treatment efficacy. The potential opportunities and pitfalls of S100B in the different areas usually refer to its specificity and sensitivity to detect and assess intracranial injury.ConclusionGiven some shortcomings that should be realized, S100B can be used as a versatile screening, monitoring and prediction tool in the management of TBI patients.

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Harms of off-label erythropoiesis-stimulating agents for critically ill people

Mesgarpour

Heidinger

Roth

et al. 2017

Cochrane Database of Systematic Reviews

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Low quality of evidence suggests that off-label use of ESAs may reduce mortality in a critical care setting. There was a lack of high-quality evidence about the harm of ESAs in critically-ill people. The information for biosimilar ESAs is less conclusive. Most studies neither evaluated ESAs' harm as a primary outcome nor predefined adverse events. Any further studies of ESA should address the quality of evaluating, recording and reporting of adverse events.

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Recombinant human erythropoietin improves functional recovery in patients with severe traumatic brain injury: A randomized, double blind and controlled clinical trial

Cited by 46 publications

References 18 publications

Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain Injury Dynamics: A Systematic Review

Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain Injury Dynamics: A Systematic Review

A review of the clinical utility of serum S100B protein levels in the assessment of traumatic brain injury

Harms of off-label erythropoiesis-stimulating agents for critically ill people

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